Short inter-stimulus intervals can be used for olfactory electroencephalography in patients of varying olfactory function

Short inter-stimulus intervals can be used for olfactory electroencephalography in patients of varying olfactory function
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短刺激间隔可用于不同嗅觉功能患者的嗅觉脑电图

DOI:
10.1016/j.neuroscience.2017.08.046
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发表时间:
2017
期刊:
影响因子:
3.3
通讯作者:
Thomas Hummel
Thomas Hummel
中科院分区:
医学3区
文献类型:
--
作者:
K. Whitcroft;K. Whitcroft;K. Whitcroft;M. Aziz;Ilona Croy;Valentin A. Schriever;Thomas Hummel

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化学感觉事件相关电位(ERPs)的使用受到相对较差的信噪比(SNRs)的限制。我们假设,通过减少标准刺激间间隔(ISI),增加试验重复次数可能会增加信噪比。为了进一步研究这一点,我们进行了迄今为止最大规模的研究,在101名不同嗅觉功能的参与者中使用短和长ISIs来评估化学感觉ERP。使用玫瑰气味(苯乙基醇,PEA)作为一种相对选择性的嗅觉兴奋剂,我们发现使用短或长ISIs记录erp的个体比例没有显着差异。这在正常嗅觉者、低嗅觉者和功能性嗅觉者中都是正确的。我们还证明,在正常和功能性嗅觉缺失组中,使用短PEA-ISIs可以显著提高信噪比。在不同嗅觉功能组之间进行比较,在PEA-10s方案下,低嗅觉患者比正常嗅觉患者发作更快,幅度更大。这可能是由于刺激增加的出席,但需要进一步的研究证实。
Use of chemosensory event-related potentials (ERPs) is limited by relatively poor signal-to-noise ratios (SNRs). We hypothesized that by reducing the standard inter-stimulus interval (ISI), the increased number of trial repetitions possible may increase SNR. In order to further investigate this, we performed the largest study to date assessing chemosensory ERP using short and long ISIs in 101 participants of varying olfactory function. Using rose odor (phenylethylalcohol, PEA) as a relatively selective olfactory stimulant, we found no significant difference in the proportion of individuals in whom ERPs were recorded using short or long ISIs. This was true in normosmic, hyposmic and functionally anosmic individuals. We also demonstrated significantly increased SNR using short PEA-ISIs, in the normosmic and functionally anosmic groups. Comparing between groups of different olfactory function, hyposmic patients achieved faster onsets and greater amplitudes than normosmics under the PEA-10s protocol. This could be due to increased stimulus attendance, but requires confirmation with further research.
DOI: 10.1093/chemse/25.4.487
发表时间: 2000-08-01
期刊: CHEMICAL SENSES
影响因子: 3.5
作者:
Dalton, P
通讯作者: Dalton, P
DOI: 10.1016/s0167-8760(99)00107-5
发表时间: 2000-05-01
影响因子: 3
作者:
Murphy, C;Morgan, CD;Polich, JM
通讯作者: Polich, JM
嗅觉事件相关电位:老年男性表现出最大的缺陷。
DOI: 10.1016/s0168-5597(97)00020-8
发表时间: 1997
期刊: Electroencephalography and clinical neurophysiology
影响因子: --
作者:
Morgan,CD;Covington,JW;Geisler,MW;Polich,J;Murphy,C
通讯作者: Murphy,C