A case of combined hepatocellular-cholangiocarcinoma with favorable response to systemic chemotherapy.
A case of combined hepatocellular-cholangiocarcinoma with favorable response to systemic chemotherapy.
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DOI：
10.4143/crt.2010.42.4.235
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发表时间：
2010-12
影响因子：
4.6
通讯作者：
Shin SJ
中科院分区：
文献类型：
--
作者：
Kim GM;Jeung HC;Kim D;Kim JH;Yoon SH;Jung ES;Shin SJ
联合性肝细胞胆管癌（cHCC-CC）是一种罕见的原发性肝癌，由具有肝细胞癌（HCC）和胆管癌（CC）组织病理学特征的细胞组成。由于其发病率低，有关 cHCC-CC 临床结果的信息非常有限，并且没有公开的报告描述 cHCC-CC 的非手术治疗方案。我们报告一例 cHCC-CC 对阿霉素和顺铂全身化疗表现出良好的反应。一名 62 岁男性因 cHCC-CC 右肺叶切除术后复发，接受索拉非尼姑息性全身治疗，但后续影像学研究显示疾病进展。他接受了二线化疗，使用 60 mg/m2 的阿霉素和 70 mg/m2 的顺铂。两个周期的化疗后，胸部计算机断层扫描显示多发性肺转移瘤的大小和数量明显减少。完成 8 个周期的二线治疗后，由于阿霉素和顺铂相关的毒性，我们将治疗方案改为氟尿嘧啶 (5-FU) 单药治疗。迄今为止，该患者已完成第15个周期的5-FU单药治疗，在18个月的随访期间疾病状态保持稳定。
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare form of primary liver cancer composed of cells with histopathologic features of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Because of its low incidence, the information on clinical outcomes of cHCC-CC is very limited and there are no published reports describing non-surgical treatment options for cHCC-CC. We report a case of cHCC-CC exhibiting a favorable response to systemic chemotherapy with doxorubicin and cisplatin. A 62-year-old man who recurred after a right lobectomy for cHCC-CC received sorafenib for palliative systemic therapy, but follow up imaging studies showed disease progression. He received 2nd line chemotherapy with doxorubicin at 60 mg/m2 together with cisplatin at 70 mg/m2. After 2 cycles of chemotherapy, a computed tomography scan of the chest showed markedly decreased size and number of the multiple lung metastases. After completing 8 cycles of 2nd line therapy, we changed the regimen to a fluorouracil (5-FU) mono therapy because of the toxicities associated with doxorubicin and cisplatin. To date, the patient has completed his 15th cycle of 5-FU mono therapy with the disease status remaining stable during 18 months of follow-up.
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影响因子：
4.2
作者：
Tanaka, S;Yamamoto, T;Kubo, S
通讯作者：
Kubo, S
DOI：
10.1111/j.1440-1746.1996.tb00327.x
发表时间：
1996-08-01
影响因子：
4.1
作者：
Taguchi, J;Nakashima, O;Kojiro, M
通讯作者：
Kojiro, M
影响因子：
6.2
作者：
Jarnagin, WR;Weber, S;Klimstra, D
通讯作者：
Klimstra, D
影响因子：
3.5
作者：
Chan, Albert Chi-Yan;Lo, Chung Mau;Fan, Sheung Tat
通讯作者：
Fan, Sheung Tat
影响因子：
4.3
作者：
Shimoda, Mitsugi;Kubota, Keiichi
通讯作者：
Kubota, Keiichi