Nitric oxide and aneurysm formation in Kawasaki disease
Nitric oxide and aneurysm formation in Kawasaki disease
复制标题
川崎病中的一氧化氮和动脉瘤形成
作者：
T. Iizuka;K. Oishi;M. Sasaki;Y. Hatanaka;Y. Minatogawa;S. Uemura;M. Koike
本研究的目的是证明一氧化氮在川崎冠状动脉异常的发展中起作用。我们检测了34名川崎病患者、24名其他疾病患者和25名健康儿童（作为对照组）的316份尿液样本中的亚硝酸盐+硝酸盐、生物蝶呤和新蝶呤，因为据报道，尿亚硝酸盐+硝酸盐可用作体内一氧化氮生成的标志物，而新蝶呤-生物蝶呤合成和一氧化氮生成的途径是紧密耦合的。在我们的研究中，患有川崎病的儿童比健康对照组儿童排出更多的尿亚硝酸盐+硝酸盐和新蝶呤，并且比患有其他疾病的患者排出异常高的量更频繁。尿亚硝酸盐+硝酸盐水平与尿生物蝶呤水平之间以及这些生物蝶呤水平与尿新蝶呤水平之间存在良好的相关性。因此，一氧化氮被认为以异常高的量产生，并且与川崎的病理学和冠状动脉异常的发展密切相关。一氧化氮在川崎病中的作用应进一步研究，以阐明疾病的病理生理学，并帮助开发新的治疗方法。
The objective of this study is to show that nitric oxide plays a role in the development of coronary artery abnormalities in Kawasaki disease. We examined nitrite + nitrate, biopterin and neopterin in 316 urine samples of 34 patients with Kawasaki disease, those of 24 patients with other diseases, and those of 25 healthy children acting as a control group, because urinary nitrite + nitrate are reportedly useful as markers of nitric oxide generation in vivo, and pathways for neopterin‐biopterin synthesis and nitric oxide generation are tightly coupled. In our study, the children with Kawasaki disease excreted more urinary nitrite + nitrate and neopterin than did the healthy control group children and excreted abnormally high quantities more often than did the patients with other diseases. Good relationships were found between the urinary nitrite + nitrate levels and the urinary biopterin levels, and between these biopterin levels and the urinary neopterin levels. Nitric oxide is therefore thought to be generated in abnormally high quantities, and to be closely related to the pathology of Kawasaki disease and to the development of coronary artery abnormalities. The role of nitric oxide in Kawasaki disease should be further studied to elucidate the pathophysiology of the disease and to aid in the development of new treatments.
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
影响因子：
37.8
作者：
COSENTINO, F;KATUSIC, ZS
通讯作者：
KATUSIC, ZS