DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function.
DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function.
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DOI：
10.3390/ijms19051315
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发表时间：
2018-04-28
影响因子：
5.6
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Cui D;Xu X
衰老是人类学习、记忆和认知能力下降/缺陷的主要原因，是年龄相关神经退行性疾病如阿尔茨海默病的主要风险因素。新出现的证据表明，表观遗传学，一个可遗传但可逆的生化过程，在年龄相关的神经系统疾病的发病机制中起着至关重要的作用。DNA甲基化是最著名的表观遗传标记，在这方面引起了最多的关注。DNA甲基转移酶（DNMT）是介导DNA甲基化过程的关键酶，通过该过程，甲基被忠实地或重新地转移到基因组DNA序列。在生物学上，DNMT对于基因印记是重要的。越来越多的证据表明，DNMTs不仅在中枢神经系统（CNS）的早期发育阶段发挥关键作用，包括基因印迹和转录调控，而且在成人学习，记忆和认知中也是不可或缺的。因此，DNMT和DNA甲基化对年龄相关的认知功能和神经退行性疾病的影响已成为该领域的关键课题。在这篇综述中，讨论了每种DNMT对中枢神经系统发育以及健康和病理性衰老的影响。
Ageing, a leading cause of the decline/deficits in human learning, memory, and cognitive abilities, is a major risk factor for age-associated neurodegenerative disorders such as Alzheimer’s disease. Emerging evidence suggests that epigenetics, an inheritable but reversible biochemical process, plays a crucial role in the pathogenesis of age-related neurological disorders. DNA methylation, the best-known epigenetic mark, has attracted most attention in this regard. DNA methyltransferases (DNMTs) are key enzymes in mediating the DNA methylation process, by which a methyl group is transferred, faithfully or anew, to genomic DNA sequences. Biologically, DNMTs are important for gene imprinting. Accumulating evidence suggests that DNMTs not only play critical roles, including gene imprinting and transcription regulation, in early development stages of the central nervous system (CNS), but also are indispensable in adult learning, memory, and cognition. Therefore, the impact of DNMTs and DNA methylation on age-associated cognitive functions and neurodegenerative diseases has emerged as a pivotal topic in the field. In this review, the effects of each DNMT on CNS development and healthy and pathological ageing are discussed.
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Dnmt1 和 Dnmt3a 维持 DNA 甲基化并调节成人前脑神经元的突触功能
影响因子：
25
作者：
Feng, Jian;Zhou, Yu;Campbell, Susan L.;Le, Thuc;Li, En;Sweatt, J. David;Silva, Alcino J.;Fan, Guoping
通讯作者：
Fan, Guoping
影响因子：
4.8
作者：
Cohen, J D;Forman, S D;Noll, D C
通讯作者：
Noll, D C
DOI：
10.3233/adr-170015
发表时间：
2017-09-13
期刊：
Journal of Alzheimer's disease reports
影响因子：
--
作者：
Boden KA;Barber IS;Clement N;Patel T;Guetta-Baranes T;Brookes KJ;Chappell S;Craigon J;Chapman NH;ARUK Consortium;Morgan K;Seymour GB;Bottley A
通讯作者：
Bottley A
DOI：
10.1177/1073858417707457
发表时间：
2018-04
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bayraktar G;Kreutz MR
通讯作者：
Kreutz MR
影响因子：
25
作者：
De Jager, Philip L.;Srivastava, Gyan;Lunnon, Katie;Burgess, Jeremy;Schalkwyk, Leonard C.;Yu, Lei;Eaton, Matthew L.;Keenan, Brendan T.;Ernst, Jason;McCabe, Cristin;Tang, Anna;Raj, Towfique;Replogle, Joseph;Brodeur, Wendy;Gabriel, Stacey;Chai, High S.;Younkin, Curtis;Younkin, Steven G.;Zou, Fanggeng;Szyf, Moshe;Epstein, Charles B.;Schneider, Julie A.;Bernstein, Bradley E.;Meissner, Alex;Ertekin-Taner, Nilufer;Chibnik, Lori B.;Kellis, Manolis;Mill, Jonathan;Bennett, David A.
通讯作者：
Bennett, David A.