Shared genetic effects between age at menarche and disordered eating.
Shared genetic effects between age at menarche and disordered eating.
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DOI：
10.1016/j.jadohealth.2012.02.013
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发表时间：
2012-11
影响因子：
7.6
通讯作者：
Lichtenstein, Paul
中科院分区：
文献类型：
--
作者：
Baker, Jessica H.;Thornton, Laura M.;Bulik, Cynthia M.;Kendler, Kenneth S.;Lichtenstein, Paul
月经初潮过早与女性饮食失调有关。然而，尚不清楚它们是否具有共同的遗传因素。当前研究的目标是描绘初潮年龄与饮食失调之间的遗传相关性。参与者包括来自瑞典儿童和青少年发展双胞胎研究的 427 名同卵双胞胎和 329 名异卵 16-17 岁女性双胞胎。使用饮食失调量表 2 评估饮食失调。通过自我报告评估初潮年龄。使用双变量相关因素模型来描述初潮年龄与饮食失调之间的遗传相关性。分析显示，最佳拟合模型中的负遗传相关性为 -.18，表明影响初潮年龄较轻的遗传因素与饮食失调的可能性增加有关。未来的研究应该检查这种相关性的可能原因，例如雌激素系统和基因-环境相互作用。
An early age at menarche is associated with disordered eating in women. However, it is unclear whether they share genetic factors. The goal of the current study is to delineate the genetic correlation between age at menarche and disordered eating. Participants included 427 monozygotic and 329 dizygotic 16-17 year-old female twins from the Swedish Twin Study of Child and Adolescent Development. Disordered eating was assessed with the Eating Disorder Inventory-2. Age at menarche was assessed via self-report. A bivariate correlated factors model was used to delineate the genetic correlation between age at menarche and disordered eating. The analysis revealed a negative genetic correlation of −.18 in the best-fit model indicating that the genetic factors that influence younger age at menarche are associated with increased liability for disordered eating. Future research should examine possible causes for this correlation such as the estrogen system and gene-environment interactions.
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