Decreased levels of S-100 protein in non-ulcer interstitial cystitis.
Decreased levels of S-100 protein in non-ulcer interstitial cystitis.
复制标题
非溃疡性间质性膀胱炎中 S-100 蛋白水平降低。
DOI：
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发表时间：
1998
影响因子：
--
通讯作者：
Magnus Fall
中科院分区：
文献类型：
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作者：
R. Peeker;Frank Aldenborg;K. G. Haglid;Sonny L. Johansson;Lars Rosengren;Magnus Fall
间质性膀胱炎（IC）是一种慢性衰弱性疾病，主要影响女性。积累的证据表明 IC 是一种异质综合征。与经典 IC 相比，非溃疡型 IC 在症状、内镜和组织学检查结果以及对各种治疗形式的反应方面似乎有所不同。 S-100 是一种神经蛋白，被认为主要位于轴突中。为了进一步探讨该疾病的神经源性本质，我们比较了对照组以及经典和非溃疡性 IC 患者的膀胱壁 S-100 含量。我们注意到与对照相比，非溃疡 IC 中的 S-100 含量有所减少。这可能是非溃疡性 IC 中周围神经分布改变的表现，而这反过来又可能是原发性神经源性病因的指征。经典和非溃疡 IC 之间 S-100 含量的差异支持了它们代表不同实体的假设，这可能解释了对各种治疗的反应差异。
Interstitial cystitis (IC) is a chronic debilitating condition which mainly affects women. Accumulated evidence indicates that IC is a heterogeneous syndrome. As compared to classic IC, the non-ulcer type of IC appears to be different concerning symptomatic, endoscopical and histological findings, as well as in response to various forms of treatment. S-100 is a neural protein considered to be located primarily in the axons. To explore further the neurogenic nature of the disease, we compared bladder wall S-100 content in controls and in patients with classic and non-ulcer IC. We noticed a decrease in S-100 content in non-ulcer IC as compared to controls. This may be an expression of altered peripheral innervation in non-ulcer IC, which, in turn, may be an indication of primary neurogenic etiology. The difference in S-100 content between classic and non-ulcer IC supports the hypothesis that they represent separate entities, which may explain differences in response to various treatments.
DOI：
10.1002/neu.480230410
发表时间：
1992-06-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
BHATTACHARYYA, A;OPPENHEIM, RW;RATNER, N
通讯作者：
RATNER, N