Interaction of motor training and intermittent theta burst stimulation in modulating motor cortical plasticity: influence of BDNF Val66Met polymorphism.
Interaction of motor training and intermittent theta burst stimulation in modulating motor cortical plasticity: influence of BDNF Val66Met polymorphism.
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DOI：
10.1371/journal.pone.0057690
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lee HW
中科院分区：
文献类型：
--
作者：
Lee M;Kim SE;Kim WS;Lee J;Yoo HK;Park KD;Choi KG;Jeong SY;Kim BG;Lee HW
行为运动训练（MT）和重复经颅磁刺激方案（如间歇性θ波爆发刺激（iTBS））对人类运动皮层的皮质生理有影响。本研究旨在测试MT和iTBS是否可以相互作用，产生累加性的运动皮质生理变化。我们假设MT和iTBS之间的潜在相互作用将依赖于BDNF Val66Met多态性，该多态性已知会影响人类运动皮层的神经可塑性。对82名健康志愿者进行BDNF多态性基因分型。30名受试者单独接受MT， 23名受试者单独接受iTBS， 29名受试者接受MT + iTBS。在每个范式之前和之后测量皮层兴奋性和运动图区域的TMS指数。单纯MT可显著增加运动皮质兴奋性，扩大运动地图区域。单独iTBS模式也增强了兴奋性，增加了运动地图区域，其程度略高于单独MT。在Val/Val基因型中，MT + iTBS的代表性运动图扩张明显大于MT或单独iTBS。因此，MT和iTBS之间的加性相互作用高度依赖于BDNF Val66Met多态性。我们的研究结果可能对设计运动障碍患者结合治疗性皮质刺激和体育锻炼的康复策略具有临床意义。
Cortical physiology in human motor cortex is influenced by behavioral motor training (MT) as well as repetitive transcranial magnetic stimulation protocol such as intermittent theta burst stimulation (iTBS). This study aimed to test whether MT and iTBS can interact with each other to produce additive changes in motor cortical physiology. We hypothesized that potential interaction between MT and iTBS would be dependent on BDNF Val66Met polymorphism, which is known to affect neuroplasticity in the human motor cortex. Eighty two healthy volunteers were genotyped for BDNF polymorphism. Thirty subjects were assigned for MT alone, 23 for iTBS alone, and 29 for MT + iTBS paradigms. TMS indices for cortical excitability and motor map areas were measured prior to and after each paradigm. MT alone significantly increased the motor cortical excitability and expanded the motor map areas. The iTBS alone paradigm also enhanced excitability and increased the motor map areas to a slightly greater extent than MT alone. A combination of MT and iTBS resulted in the largest increases in the cortical excitability, and the representational motor map expansion of MT + iTBS was significantly greater than MT or iTBS alone only in Val/Val genotype. As a result, the additive interaction between MT and iTBS was highly dependent on BDNF Val66Met polymorphism. Our results may have clinical relevance in designing rehabilitative strategies that combine therapeutic cortical stimulation and physical exercise for patients with motor disabilities.
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影响因子：
5.5
作者：
Cheeran, Binith;Talelli, Penelope;Rothwell, John C.
通讯作者：
Rothwell, John C.
DOI：
10.1016/s0921-884x(96)96021-x
发表时间：
1996-12-01
期刊：
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Kaneko, K;Kawai, S;Ofuji, A
通讯作者：
Ofuji, A
影响因子：
5.3
作者：
Gersner, Roman;Kravetz, Elena;Zangen, Abraham
通讯作者：
Zangen, Abraham
影响因子：
11.2
作者：
Bütefisch, CM;Davis, BC;Cohen, LG
通讯作者：
Cohen, LG
影响因子：
5.5
作者：
BLISS, TVP;LOMO, T
通讯作者：
LOMO, T