Performance of two clinical scales to assess quality of life in patients with post-thrombotic syndrome.
Performance of two clinical scales to assess quality of life in patients with post-thrombotic syndrome.
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DOI：
10.1016/j.jvsv.2021.01.017
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Kahn SR
中科院分区：
文献类型：
--
作者：
Lee A;Gu CS;Vedantham S;Kearon C;Blostein M;Kahn SR
直接比较Villalta量表和静脉临床严重程度评分（VCSS），并根据患者报告的生活质量（QoL）评分，确定两种测量方法中哪一种更能捕获临床重要的血栓后综合征（PTS）和PTS严重程度。我们对急性静脉血栓形成进行了二次分析：用辅助导管定向溶栓去除血栓（attraction）试验研究人群。我们计算了每次研究访问（随访6个月、12个月、18个月和24个月）时Villalta评分和VCSS评分与生活质量评分(健康调查表-36生理成分评分/精神成分评分[SF-36 PCS/MCS]；静脉功能不全流行病学和经济研究-生活质量/症状问卷（veins -QoL/Sym）的相关性。使用多变量纵向模型评估Villalta、VCSS和venes - qol /Sym评分之间的随机截距（平均得分）和随机斜率（得分变化率）的相关性。Villalta评分与VCSS评分的中位相关系数为0.72。所有随访时Villalta评分与VEINES-QoL和VEINES-Sym评分的相关性中位数分别为- 0.68和- 0.71。Villalta评分与sf - 36pcs和sf - 36mcs评分的相关性中位数分别为- 0.51和- 0.31。对于VCSS，在所有随访中与VEINES-QoL和VEINES-Sym评分的相关性中位数分别为- 0.39和- 0.41。在VCSS与sf - 36pcs和sf - 36mcs评分之间，相关性的中位数分别为- 0.32和- 0.13。多变量纵向模型中随机效应之间的相关性具有类似的模式。年龄、性别和体重指数的协变量调整影响较小。Villalta得分与VCSS得分呈强相关。Villalta量表与静脉疾病特异性和一般生活质量的相关性明显高于VCSS。我们的研究结果表明，当使用单一量表来评估有临床意义的PTS时，Villalta量表将更好地捕捉PTS对患者报告的生活质量的影响。一项对急性静脉血栓形成的二次分析：辅助导管定向溶栓去除血栓（多中心随机对照）试验表明，与静脉临床严重程度评分相比，Villalta量表和生活质量指标之间存在更强的相关性。
To directly compare the Villalta scale and the Venous Clinical Severity Score (VCSS) and determine which of the two measures is better at capturing clinically important post-thrombotic syndrome (PTS) and PTS severity, as measured against patient-reported quality of life (QoL) scores. We performed a secondary analysis of the Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) trial study population. We calculated the correlations of the Villalta scores and VCSS scores with QoL scores (Short-Form Health Survey-36 physical component score/mental component score [SF-36 PCS/MCS]; Venous Insufficiency Epidemiological and Economic Study-QoL/Symptom questionnaire (VEINES-QoL/Sym) at each study visit (6-month, 12-month, 18-month and 24-month follow-up). The correlation of the random intercept (mean scores) and random slope (rate of change of the scores) between the Villalta, VCSS and VEINES-QoL/Sym scores was assessed using a multivariate longitudinal model. The median correlation between Villalta scores and VCSS score was 0.72. The median of the correlations between Villalta scores and VEINES-QoL and VEINES-Sym scores at all follow-up visits were −0.68 and −0.71, respectively. Between Villalta scores and SF-36 PCS and SF-36 MCS scores, the median of the correlations were −0.51 and −0.31, respectively. For VCSS, the median of the correlations with VEINES-QoL and VEINES-Sym scores at all follow-up visits were −0.39 and −0.41, respectively. Between VCSS and SF-36 PCS and SF-36 MCS scores, the median of the correlations were −0.32 and −0.13, respectively. Correlations between random effects in multivariate longitudinal models had a similar pattern. The impact of covariate adjustment by age, sex and body mass index was minor. Villalta scores and VCSS scores are strongly correlated. The Villalta scale has a substantially higher correlation with venous disease specific and general QoL than the VCSS. Our findings suggest that when a single scale is used to assess clinically-meaningful PTS, the Villalta scale will better capture the impact of PTS on patient reported QoL. A secondary analysis of the Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (multicenter randomized controlled) trial demonstrated a stronger correlation between the Villalta Scale and quality of life measures compared to the Venous Clinical Severity Score.
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DOI：
10.1056/nejmoa1615066
发表时间：
2017-12-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Vedantham S;Goldhaber SZ;Julian JA;Kahn SR;Jaff MR;Cohen DJ;Magnuson E;Razavi MK;Comerota AJ;Gornik HL;Murphy TP;Lewis L;Duncan JR;Nieters P;Derfler MC;Filion M;Gu CS;Kee S;Schneider J;Saad N;Blinder M;Moll S;Sacks D;Lin J;Rundback J;Garcia M;Razdan R;VanderWoude E;Marques V;Kearon C;ATTRACT Trial Investigators
通讯作者：
ATTRACT Trial Investigators
影响因子：
4.3
作者：
Meissner, MH;Natiello, C;Nicholls, SC
通讯作者：
Nicholls, SC
影响因子：
--
作者：
Kahn, SR;Hirsch, A;Shrier, I
通讯作者：
Shrier, I
影响因子：
4
作者：
Ashrani, Aneel A.;Heit, John A.
通讯作者：
Heit, John A.
影响因子：
4.3
作者：
Rutherford, RB;Padberg, FT;Moneta, GL
通讯作者：
Moneta, GL