Brain metabolic DNA in memory processing and genome turnover
Brain metabolic DNA in memory processing and genome turnover
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记忆处理和基因组周转中的大脑代谢 DNA
DOI：
10.1515/revneuro-2016-0027
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发表时间：
2017
影响因子：
4.1
通讯作者：
A. Sadile
中科院分区：
文献类型：
--
作者：
A. Giuditta;G. Grassi;A. Sadile
目前，复杂的方法被用于研究脑DNA的特性，并阐明其在生理条件下以及在神经和精神疾病中的作用。现在需要注意的是存在于成年大鼠大脑中的DNA片段，其特征是高周转率，不参与细胞分裂或DNA修复。这部分被称为脑代谢DNA (BMD)，受压力、压力、昼夜节律波动、暴露于丰富或贫瘠的环境，尤其是几种训练方案和试验后睡眠的调节。BMD通常局限于神经胶质细胞，但也存在于神经元中，通常在核周区。它在重复和非重复DNA片段中的分布表明，学习大鼠的骨密度与天然DNA不同，也表明学习大鼠的骨密度与对照大鼠不同。更详细地了解分子、细胞和时间依赖的骨密度特征，将有助于确定其在记忆获取和加工以及神经系统疾病发病机制中的作用。
Abstract Sophisticated methods are currently used to investigate the properties of brain DNA and clarify its role under physiological conditions and in neurological and psychiatric disorders. Attention is now called on a DNA fraction present in the adult rat brain that is characterized by an elevated turnover and is not involved in cell division or DNA repair. The fraction, known as brain metabolic DNA (BMD), is modulated by strain, stress, circadian oscillations, exposure to enriched or impoverished environment, and notably by several training protocols and post-trial sleep. BMD is frequently localized in glial cells but is also present in neurons, often in the perinucleolar region. Its distribution in repetitive and non-repetitive DNA fractions shows that BMD differs from native DNA and that in learning rats its profile differs from that of control rats. More detailed knowledge of the molecular, cellular, and time-dependent BMD features will be necessary to define its role in memory acquisition and processing and in the pathogenesis of neurologic disorders.
影响因子：
7.3
作者：
Bushman, Diane M.;Chun, Jerold
通讯作者：
Chun, Jerold