T cell-mediated modulation of mast cell function: heterotypic adhesion-induced stimulatory or inhibitory effects.
T cell-mediated modulation of mast cell function: heterotypic adhesion-induced stimulatory or inhibitory effects.
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DOI：
10.3389/fimmu.2012.00006
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发表时间：
2012
影响因子：
7.3
通讯作者：
Hershko AY
中科院分区：
文献类型：
--
作者：
Mekori YA;Hershko AY
肥大细胞和T细胞之间的紧密物理接近已经在几种T细胞介导的炎症过程中被证明，如类风湿性关节炎和结节病。然而，肥大细胞在这些T细胞介导的免疫应答中被激活的方式尚未完全阐明。我们已经确定并表征了一种新的肥大细胞活化途径，该途径由与活化的T细胞的物理接触引发，并表明该途径与脱粒和细胞因子释放相关。与肥大细胞活化的这一途径相关的信号传导事件也已阐明，证实Ras促分裂原活化蛋白激酶系统的活化。最近，我们假设并证明肥大细胞也可能被活化T细胞释放的微粒激活，这些微粒被认为是细胞的微型版本。通过扩展，微粒可能会影响肥大细胞的活性，肥大细胞通常不与炎症部位的T细胞直接接触。最近的工作也集中在调节性T细胞（Treg）对肥大细胞的影响。这些报告强调了肥大细胞和T细胞分别产生的细胞因子IL-2和IL-9在获得最佳免疫抑制中的重要性。最后，已经发现与OX 40-OX 40 L接合相关的物理接触是Treg对肥大细胞功能施加的下调作用的基础。
Close physical proximity between mast cells and T cells has been demonstrated in several T cell mediated inflammatory processes such as rheumatoid arthritis and sarcoidosis. However, the way by which mast cells are activated in these T cell-mediated immune responses has not been fully elucidated. We have identified and characterized a novel mast cell activation pathway initiated by physical contact with activated T cells, and showed that this pathway is associated with degranulation and cytokine release. The signaling events associated with this pathway of mast cell activation have also been elucidated confirming the activation of the Ras mitogen-activated protein kinase systems. More recently, we hypothesized and demonstrated that mast cells may also be activated by microparticles released from activated T cells that are considered as miniature version of a cell. By extension, microparticles might affect the activity of mast cells, which are usually not in direct contact with T cells at the inflammatory site. Recent works have also focused on the effects of regulatory T cells (Treg) on mast cells. These reports highlighted the importance of the cytokines IL-2 and IL-9, produced by mast cells and T cells, respectively, in obtaining optimal immune suppression. Finally, physical contact, associated by OX40–OX40L engagement has been found to underlie the down-regulatory effects exerted by Treg on mast cell function.
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影响因子：
6.1
作者：
Brill, A;Baram, D;Hershkoviz, R
通讯作者：
Hershkoviz, R
影响因子：
32.4
作者：
Gri G;Piconese S;Frossi B;Manfroi V;Merluzzi S;Tripodo C;Viola A;Odom S;Rivera J;Colombo MP;Pucillo CE
通讯作者：
Pucillo CE
影响因子：
12.4
作者：
Salamon, P;Shoham, NG;Mekori, YA
通讯作者：
Mekori, YA
影响因子：
4.4
作者：
Baram, Dana;Dekel, Ornit;Sagi-Eisenberg, Ronit
通讯作者：
Sagi-Eisenberg, Ronit
肥大细胞通过肿瘤坏死因子和巨噬细胞炎症蛋白2控制T细胞介导的延迟型超敏反应期间的中性粒细胞募集。
影响因子：
15.3
作者：
Biedermann, T;Kneilling, M;Mailhammer, R;Maier, K;Sander, C A;Kollias, G;Kunkel, S L;Hultner, L;Rocken, M
通讯作者：
Rocken, M