Increased p16 Expression in High-grade Serous and Undifferentiated Carcinoma Compared With Other Morphologic Types of Ovarian Carcinoma
Increased p16 Expression in High-grade Serous and Undifferentiated Carcinoma Compared With Other Morphologic Types of Ovarian Carcinoma
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与其他形态类型的卵巢癌相比，高级别浆液性和未分化癌中 p16 表达增加
DOI：
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发表时间：
2009
影响因子：
2.4
通讯作者：
W. Mccluggage
中科院分区：
文献类型：
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作者：
V. Phillips;P. Kelly;W. Mccluggage
卵巢癌有几种形态学类型。研究表明，p16在高级别浆液性癌中过表达，但在常见类型的卵巢癌中p16表达的详细比较很少。本研究的目的是比较p16在浆液性、类浆液性、透明细胞和粘液性卵巢癌中的表达，以确定原发性卵巢癌中的高表达是否是浆液性肿瘤的特异性。我们纳入了难以分型的问题病例，如低分化和未分化癌以及透明细胞浆液性癌。在这些有问题的群体中，我们比较了p16表达与WT 1，这是已知的是相对具体的浆液性表型。卵巢高级别浆液性癌38例，类浆液性癌15例，透明细胞癌12例，粘液性癌10例。对病例进行免疫反应性分布（0-5）和强度（0-3）评分。还通过乘以分布和强度评分计算免疫组织化学综合评分（0-15）。浆液性癌通常表现出高p16表达，有统计学意义的高p16表达浆液性癌与其他形态类型相比。在大多数未分化癌和透明细胞的浆液性癌中，p16和WT 1表达较高，表明这些代表浆液性癌的变体。我们已经证明，与其他形态类型的卵巢癌相比，p16在高级别浆液性和未分化癌中高表达。这可能是有用的，结合WT 1，在有问题的肿瘤的分类。p16可能通过视网膜母细胞瘤蛋白的失活而参与高级别卵巢浆液性癌的发病机制。
There are several morphologic types of ovarian carcinoma. It has been shown that p16 is overexpressed in high-grade serous carcinoma but there has been little detailed comparison of p16 expression in the common types of ovarian carcinoma. The aim of this study was to compare p16 expression in ovarian carcinomas of serous, endometrioid, clear cell, and mucinous type with a view to ascertaining whether high expression in a primary ovarian carcinoma is specific for a serous neoplasm. We included problematic cases, which are difficult to type, such as poorly differentiated and undifferentiated carcinomas and serous carcinomas with clear cells. In these problematic groups, we compared p16 expression with that of WT1, which is known to be relatively specific for a serous phenotype. Cases of ovarian high-grade serous carcinoma (n=38), endometrioid carcinoma (n=15), clear cell carcinoma (n=12), and mucinous carcinoma (n=10) were stained with p16. Cases were scored both with respect to distribution of immunoreactivity (0–5) and intensity (0–3). An immunohistochemical composite score was also calculated (0–15) by multiplying the distribution and intensity scores. Serous carcinomas typically exhibited high p16 expression; there was statistically significant higher p16 expression in serous carcinomas compared with the other morphologic types. There was high p16 and WT1 expression in most undifferentiated carcinomas and in serous carcinomas with clear cells, suggesting that these represent variants of serous carcinoma. We have demonstrated that p16 is highly expressed in high-grade serous and undifferentiated carcinomas compared with other morphologic types of ovarian carcinoma. This may be useful, in conjunction with WT1, in the classification of problematic neoplasms. p16 may be involved in the pathogenesis of high-grade ovarian serous carcinomas, possibly through inactivation of retinoblastoma protein.
DOI：
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发表时间：
1999-09
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Gunnlaugur P. Nielsen;A. Stemmer-Rachamimov;J. Shaw;Jennifer E. Roy;J. Koh;David N. Louis
通讯作者：
Gunnlaugur P. Nielsen;A. Stemmer-Rachamimov;J. Shaw;Jennifer E. Roy;J. Koh;David N. Louis