Lower levels of vWF are associated with lower risk of cardiovascular disease.
Lower levels of vWF are associated with lower risk of cardiovascular disease.
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DOI：
10.1002/rth2.12797
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发表时间：
2022-10
影响因子：
4.6
通讯作者：
Spronk, Henri M. H.
中科院分区：
文献类型：
--
作者：
van Paridon, Pauline C. S.;Panova-Noeva, Marina;van Oerle, Rene;Schulz, Andreas;Prochaska, Juergen H.;Arnold, Natalie;Schmidtmann, Irene;Beutel, Manfred;Pfeiffer, Norbert;Muenzel, Thomas;Lackner, Karl J.;ten Cate, Hugo;Wild, Philipp S.;Spronk, Henri M. H.
目前的研究是前瞻性地探讨是否有低水平的血管性血友病因子（vWF）抗原和vWF活性降低心血管疾病和死亡的风险。在2007年4月至2008年10月期间入组基于人群的古滕贝格健康研究的4857名年龄在35 - 74岁之间的个体的子样本中，分别通过酶联免疫吸附试验和基于免疫学的试验测量VWF抗原和vWF活性。低于第20百分位数的VWF抗原和活性被设定为“低vWF”的量度。采用调整后的稳健Poisson回归模型分析低vWF与心血管疾病（CVD）发病率之间的关系。计算经校正的考克斯回归模型以及累积发生率曲线，以探索全因和心血管死亡率与低vWF之间的关系。VWF活性水平<第20百分位（即，<76.2%）与CVD相对风险降低相关（RR：0.59，95%CI：0.37-0.95），尽管调整了年龄和性别。调整F-VIII水平后，相关性持续存在（RR：0.60，95% CI：0.36-0.99）。累积发病率曲线显示vWF抗原<第20百分位数与心血管死亡率降低显著相关。VWF抗原<第20百分位（即，<83%）与全因死亡率风险降低显著相关，尽管调整了临床因素（RR：61，95%CI：0.41-0.91）。该研究表明，vWF活性水平低与CVD风险较低相关。此外，它揭示了低水平vWF抗原的个体心血管和全因死亡率的风险降低，为vWF作为新疗法的潜在靶点提供了新的线索。
The current study was undertaken to prospectively explore whether having low levels of von Willebrand factor (vWF) antigen and vWF activity reduce the risk for cardiovascular disease and death. VWF antigen and vWF activity were measured by enzyme‐linked immunosorbent assay and an immunological‐based assay, respectively, in a subsample of 4857 individuals aged between 35 and 74 years old, enrolled between April 2007 and October 2008 in the population‐based Gutenberg Health Study. VWF antigen and activity below the 20th percentile was set as a measure of “low vWF.” Adjusted robust Poisson regression models were used to analyze the relation between low vWF and the incidence of cardiovascular disease (CVD). Consequent adjusted cox regression models as well as cumulative incidence plots were calculated to explore the relation between all‐cause and cardiovascular mortality and low vWF. VWF activity levels <20th percentile (i.e., <76.2%) were associated with a decreased relative risk for CVD (RR: 0.59, 95% CI: 0.37–0.95), despite adjusting for age and sex. After adjusting for levels of F‐VIII, the association persisted (RR: 0.60, 95% CI: 0.36–0.99). The cumulative incidence plots demonstrated that vWF antigen <20th percentile significantly correlated with decreased cardiovascular mortality. VWF antigen<20th percentile (i.e., <83%) was significantly associated with lower risk of all‐cause mortality, despite adjusting for clinical factors (RR: 61, 95% CI: 0.41–0.91). The study demonstrated that having low vWF activity levels were associated with a lower risk for CVD. Additionally, it revealed a decreased risk of cardiovascular and all‐cause mortality in individuals with low levels of vWF antigen, shining new light on vWF as a potential target for novel therapies.
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