PREVALENCE OF HELICOBACTER PYLORI INFECTION MEASURED WITH URINARY ANTIBODY IN AN URBAN AREA OF JAPAN, 2008–2010
PREVALENCE OF HELICOBACTER PYLORI INFECTION MEASURED WITH URINARY ANTIBODY IN AN URBAN AREA OF JAPAN, 2008–2010
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2008-2010 年日本城市地区通过尿液抗体测量的幽门螺杆菌感染患病率
DOI：
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发表时间：
2012
影响因子：
0.9
通讯作者：
N. Hamajima
中科院分区：
文献类型：
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作者：
T. Tamura;Emi Morita;T. Kondo;J. Ueyama;Tetsuya Tanaka;Yuto Kida;Y. Hori;Shigeru Inoue;Koutaro Tomita;R. Okada;S. Kawai;A. Hishida;M. Naito;K. Wakai;N. Hamajima
幽门螺杆菌（Helicobacter pylori， H. pylori）已经扩展到感染世界上大约一半的人口。虽然在20世纪90年代有许多关于幽门螺杆菌感染在世界范围内特定地区流行的研究，但只有有限的来源追踪其在大量人群中的最新流行情况。在本研究中，我们估计了幽门螺杆菌在日本城市名古屋居民中的患病率。研究对象是5167名参与者（1467名男性和3700名女性），年龄在35至69岁之间，来自Daiko研究，这是日本多机构合作队列研究（J-MICC研究）的一部分。尿中抗h抗体。采用幽门螺杆菌抗体检测幽门螺杆菌感染。通过自我填写的问卷获得幽门螺杆菌感染根除治疗史。尿检检出率为35 ~ 39岁19.6%(95%可信区间16.8 ~ 22.6%)，40 ~ 49岁25.8%(23.5 ~ 28.2%)，50 ~ 59岁39.4%(36.8 ~ 42.1%)，60 ~ 69岁50.3%(47.8 ~ 52.7%),36.4%（35.1 ~ 37.7%）。在5167名参与者中，266人（5.1%）表示他们接受了根除治疗。由于167名尿检呈阴性的受试者回答说他们过去曾对幽门螺杆菌呈血清阳性，因此他们被纳入了曾经感染过幽门螺杆菌的居民组。有持续感染史的总比例为39.6%（38.3 ~ 40.9%）。在名古屋观察到的幽门螺杆菌感染率似乎低于日本其他研究报告的相应患病率。这种较低的比率可能是由于城市卫生条件的改善减少了接触。
ABSTRACT Helicobacter pylori (H. pylori) has expanded to infect about half the world’s population. Although there were many studies on the prevalence of H. pylori infection for defined areas in the 1990s throughout the world, there were only limited sources tracking its latest prevalence among large populations. In the present study, we estimated the prevalence of H. pylori among the inhabitants of Nagoya, an urban area of Japan. Study subjects were 5,167 participants (1,467 males and 3,700 females) aged 35 to 69 years from the Daiko Study, a part of the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). A urinary anti-H. pylori antibody was used to detect H. pylori infection. The history of eradication treatments for H. pylori infection was obtained using self-administered questionnaires. The prevalence detected by the urinary test included 19.6% (95% confidence interval; 16.8–22.6%) for those aged 35–39 years, 25.8% (23.5–28.2%) for 40–49 years, 39.4% (36.8–42.1%) for 50–59 years, 50.3% (47.8–52.7%) for 60–69 years, and 36.4% (35.1–37.7%). Among 5,167 participants, 266 (5.1%) stated that they had received an eradication treatment. Since 167 subjects with negative urinary tests replied that they had been seropositive for H. pylori in the past, they were included among the ever-infected inhabitant group. Consequently, the overall rate of those with a history of persistent infection was 39.6% (38.3–40.9%). The prevalence of H. pylori infection observed in Nagoya seemed to be lower than the corresponding prevalence reported in other studies of Japan. That lower rate might be due to the reduced exposure from improved urban sanitary conditions.
影响因子：
4.5
作者：
Correa, P.;Piazuelo, M. B.
通讯作者：
Piazuelo, M. B.
幽门弯曲杆菌感染的流行病学。
影响因子：
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作者：
Graham,DY;Adam,E;Klein,PD;EvansJr,DJ;Evans,DG;Hazell,SL;Alpert,LC;Michaletz,PA;Yoshimura,HH
通讯作者：
Yoshimura,HH