Iron oxide nanoparticle targeted chemo-immunotherapy for triple negative breast cancer.
Iron oxide nanoparticle targeted chemo-immunotherapy for triple negative breast cancer.
复制标题
DOI：
10.1016/j.mattod.2021.08.002
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Mu QG;Lin G;Jeon M;Wang H;Chang FC;Revia RA;Yu J;Zhang M
三阴性乳腺癌很难有效治疗，因为它具有侵袭性、耐药性，而且缺乏激素治疗所需的受体，特别是在转移阶段。在这里，我们报道了一种多功能纳米制剂的开发和评价，该纳米制剂包含一个氧化铁核心，可以将细胞毒剂阿霉素和TLR3激动剂多肌苷：多胞苷(Poly IC)同时靶向地输送到乳腺癌和树突状细胞。Enoglin结合肽(EBP)被用来靶向TNBC细胞和血管上皮细胞。该纳米颗粒表现出良好的物理化学性质和肿瘤特异性靶向性。该纳米粒通过多种机制诱导肿瘤细胞凋亡，包括直接杀伤肿瘤细胞、树突状细胞启动的先天免疫反应和T细胞介导的适应性免疫反应。该纳米颗粒显著抑制肿瘤的生长和转移，并显著延长三阴性乳腺癌(TNBC)侵袭性和耐药性转移小鼠模型的生存时间。这项研究指出了一个很有希望的平台，可以显著提高治疗转移性TNBC的疗效。
Triple negative breast cancer is difficult to treat effectively, due to its aggressiveness, drug resistance, and lack of the receptors required for hormonal therapy, particularly at the metastatic stage. Here, we report the development and evaluation of a multifunctional nanoparticle formulation containing an iron oxide core that can deliver doxorubicin, a cytotoxic agent, and polyinosinic:polycytidylic acid (Poly IC), a TLR3 agonist, in a targeted and simultaneous fashion to both breast cancer and dendritic cells. Endoglin-binding peptide (EBP) is used to target both TNBC cells and vasculature epithelia. The nanoparticle demonstrates favorable physicochemical properties and a tumor-specific targeting profile. The nanoparticle induces tumor apoptosis through multiple mechanisms including direct tumor cell killing, dendritic cell-initiated innate and T cell-mediated adaptive immune responses. The nanoparticle markedly inhibits tumor growth and metastasis and substantially extends survival in an aggressive and drug-resistant metastatic mouse model of triple negative breast cancer (TNBC). This study points to a promising platform that may substantially improve the therapeutic efficacy for treating metastatic TNBC.
登录
查看更多内容
影响因子：
3.7
作者：
Bandyopadhyay A;Wang L;Agyin J;Tang Y;Lin S;Yeh IT;De K;Sun LZ
通讯作者：
Sun LZ
影响因子：
10
作者：
Hernandez-Gil, Javier;Cobaleda-Siles, Macarena;Mareque-Rivas, Juan C.
通讯作者：
Mareque-Rivas, Juan C.
影响因子：
14
作者：
Deng, Xiongwei;Cao, Minjun;Zeng, Yi
通讯作者：
Zeng, Yi
影响因子：
82.9
作者：
Fernandez, NC;Lozier, A;Zitvogel, L
通讯作者：
Zitvogel, L
影响因子：
3
作者：
Dehshahri, Ali;Sadeghpour, Hossein;Sheikhsaran, Fatemeh
通讯作者：
Sheikhsaran, Fatemeh