Lung is an important source of atrial natriuretic factor in experimental cardiomyopathy.
Lung is an important source of atrial natriuretic factor in experimental cardiomyopathy.
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肺是实验性心肌病中心房钠尿因子的重要来源。
DOI：
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发表时间：
1989
影响因子：
15.9
通讯作者：
P. Sirois
中科院分区：
文献类型：
--
作者：
J. Gutkowska;M. Nemer;M. Sole;J. Drouin;P. Sirois
水和电解质动态平衡的调节是多因素的，包括心脏和肾脏作为重要的调节中心。在心脏内，最近发现的一种激素，心钠素(ANF)，与维持水盐平衡有关。ANF主要发现于哺乳动物的心房，在包括肺在内的几个组织中也检测到少量的ANF。已经在遗传性心肌病仓鼠身上证明了ANF系统的紊乱，这是人类充血性心肌病的模型。在疾病的发展过程中，心房ANF基因的表达和储存减少，而循环ANF水平却升高。我们假设，在这些病理条件下，心外来源可能有助于心钠素的产生。在这篇文章中，我们提供了证据，在心肌病的发展过程中，心钠素的合成在金黄地鼠的肺中被刺激，表现为心钠素的mRNA和多肽水平的增加。此外，我们还证明了在肺中合成的ANF是分泌的，并且具有与循环ANF相同的层析和生物学特性。肺脏ANF的增加可能在预防肺水肿方面具有重要的生理学意义。或者，在心功能不全期间，肺可能通过增加其对血浆ANF水平的贡献而起到代偿作用。
The regulation of water and electrolyte homeostasis is multifactorial and includes the heart and kidneys as important regulatory centers. Within the heart, a recently discovered hormone, atrial natriuretic factor (ANF), has been implicated in the maintenance of water and salt balance. Primarily found in mammalian atria, ANF has been detected in low amounts in several tissues, including lungs. A disorder of the ANF system has been demonstrated in genetically cardiomyopathic hamsters, a model for human congestive cardiomyopathy. Atrial ANF gene expression and storage are decreased during development of this disease, while paradoxically, circulating levels of ANF are increased. We have hypothesized that an extracardiac source may contribute to ANF production in these pathological conditions. In this paper we provide evidence that ANF synthesis is stimulated in the lungs of hamsters during development of cardiomyopathy as revealed by increased ANF mRNA and peptide levels. Furthermore, we show that ANF synthesized in lungs is secreted and has identical chromatographic and biological properties to circulating ANF. The increased production of ANF in lungs may be physiologically important in preventing pulmonary edema. Alternatively, during cardiac dysfunction, lungs may play a compensatory role by increasing their contribution to plasma ANF levels.
大鼠中枢神经系统心房钠尿因子基因转录本的鉴定。
DOI：
10.1073/pnas.84.8.2175
发表时间：
1987
影响因子：
11.1
作者：
Gardner,DG;Vlasuk,GP;Baxter,JD;Fiddes,JC;Lewicki,JA
通讯作者：
Lewicki,JA