A model for the regulation of follicular dendritic cells predicts invariant reciprocal-time decay of post-vaccine antibody response.
A model for the regulation of follicular dendritic cells predicts invariant reciprocal-time decay of post-vaccine antibody response.
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DOI：
10.1038/icb.2017.55
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发表时间：
2017-10
影响因子：
4
通讯作者：
Almudevar A
中科院分区：
文献类型：
--
作者：
Almudevar A
滤泡树突状细胞（FDC）在体液免疫调节中起着至关重要的作用。由于它们在抗体应答诱导中的作用和它们将抗原以免疫原性形式长时间保留的能力，它们被认为是抗体长期持续存在的原因。在这篇文章中，提出了一个调节控制模型，该模型将体液免疫的持续性与FDC相关的细胞过程联系起来。这一论点包括三个要素。第一个是文献综述人群水平的疫苗接种后抗体持久性的研究。人们发现，抗体水平的倒数时间（1/t）衰减被广泛报道，在一系列的年龄，观察时间，和疫苗类型。第二个要素是细胞种群衰减的数学控制模型，其中倒数时间衰减是稳定吸引子。此外，控制效应很容易识别，导致模型的稳态控制的倒数时间衰减率。最后一个要素是FDC功能的文献综述。这揭示了模型所需的细胞特性与广泛观察到的FDC特性之间的惊人一致性，其中一些特性是这种细胞类型所独有的。所提出的模型是能够统一的FDC功能的一个监管原则下的各种不同的意见，并准确地描述形式的FDC监管和失调。许多传染性和免疫性疾病越来越多地与FDC监管相关，因此，准确了解潜在机制将对开发新疗法具有重要意义。
Follicular dendritic cells (FDC) play a crucial role in the regulation of humoral immunity. They are believed to be responsible for long-term persistence of antibody, due to their role in antibody response induction and their ability to retain antigen in immunogenic form for long periods. In this article, a regulatory control model is proposed which links persistence of humoral immunity with cellular processes associated with FDCs. The argument is comprised of three elements. The first is a literature review of population-level studies of post-vaccination antibody persistence. It is found that reciprocal-time (∝ 1/t) decay of antibody levels is widely reported, over a range of ages, observation times, and vaccine types. The second element is a mathematical control model for cell population decay for which reciprocal-time decay is a stable attractor. Additionally, control effectors are easily identified, leading to models of homeostatic control of the reciprocal-time decay rate. The final element is a literature review of FDC functionality. This reveals a striking concordance between cell properties required by the model and those widely observed of FDCs, some of which are unique to this cell type. The proposed model is able to unify a wide range of disparate observations of FDC function under one regulatory principle, and to characterize precisely forms of FDC regulation and dysregulation. Many infectious and immunological diseases are increasingly being linked to FDC regulation, therefore a precise understanding of the underlying mechanisms would be of significant benefit for the development of new therapies.
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DOI：
10.1084/jem.20111449
发表时间：
2011-11-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Wang X;Cho B;Suzuki K;Xu Y;Green JA;An J;Cyster JG
通讯作者：
Cyster JG
影响因子：
3.7
作者：
Endo F;Tabata T;Sadato D;Kawamura M;Ando N;Oboki K;Ukaji M;Kobayashi K;Kobayashi Y;Ikeda T;Shibasaki F
通讯作者：
Shibasaki F
影响因子：
32.4
作者：
Heesters, Balthasar A.;Chatterjee, Priyadarshini;Carroll, Michael C.
通讯作者：
Carroll, Michael C.
DOI：
10.1073/pnas.1610012113
发表时间：
2016-10-11
影响因子：
11.1
作者：
Melzi, Eleonora;Caporale, Marco;Palmarini, Massimo
通讯作者：
Palmarini, Massimo
DOI：
10.4161/hv.7.5.14982
发表时间：
2011-05-01
期刊：
HUMAN VACCINES
影响因子：
--
作者：
Gajdos, Vincent;Soubeyrand, Benoit;Fiquet, Anne
通讯作者：
Fiquet, Anne