Responses of plasma adrenocorticotropin, cortisol, and dehydroepiandrosterone to ovine corticotropin-releasing hormone in healthy aging men.
Responses of plasma adrenocorticotropin, cortisol, and dehydroepiandrosterone to ovine corticotropin-releasing hormone in healthy aging men.
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健康老年男性血浆促肾上腺皮质激素、皮质醇和脱氢表雄酮对绵羊促肾上腺皮质激素释放激素的反应。
DOI：
10.1210/jcem-62-4-767
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. R. Blackman
中科院分区：
文献类型：
--
作者：
Eugenia P. Pavlov;Eugenia P. Pavlov;S. Harman;S. Harman;G. P. Chrousos;D. Loriaux;M. R. Blackman;M. R. Blackman
为了评估年龄对垂体促肾上腺皮质激素释放激素（CRH）的反应以及皮质醇（F）和脱氢表雄酮（DHEA）对内源性ACTH升高的分泌反应的影响，我们测量了49名年龄21-86岁健康男性的夜间基础和绵羊CRH（oCRH; 1 mu/kg）刺激的血浆ACTH、F和DHEA浓度。通过方差分析，我们发现无论是基础浓度的ACTH或峰值ACTH反应的oCRH的幅度没有随年龄的变化。老年男性有较高的基础F水平（P <0.05），而基础血浆CBG水平和F与CBG的比值随年龄变化不显著（P> 0.1）。我们还发现，尽管老年男性的F峰反应发生得明显更早（P <0.03），但对oCRH的F峰反应的幅度并没有随年龄的增长而显著增加（P> 0.2）。DHEA的基础血浆水平随年龄的增长而显著下降（P <0.001），DHEA对内源性ACTH升高的峰值反应幅度也是如此（P <0.01）。随着年龄的增长，DHEA峰值反应的时间没有改变（P> 0.7）。我们的结论是，虽然ACTH和F的反应，晚上注射oCRH保持良好的健康老年男性，DHEA是不和谐的下降。目前的研究结果是相容的假设，有减少的敏感性ACTH分泌负反馈调节糖皮质激素在老年男性，有一个ACTH非依赖性的年龄相关的减少肾上腺雄激素分泌。
To assess the effects of age on both the pituitary ACTH response to corticotropin-releasing hormone (CRH) and the secretory responses of cortisol (F) and dehydroepiandrosterone (DHEA) to endogenous rises in ACTH, we measured evening basal and ovine CRH (oCRH; 1 mu/kg)-stimulated plasma concentrations of ACTH,F, and DHEA in 49 healthy men, aged 21-86 yr. By analysis of variance, we found no change with age in either the basal concentration of ACTH or the magnitude of the peak ACTH response to oCRH. Older men had higher basal F levels (P less than 0.05), while basal plasma levels of CBG and ratios of F to CBG did not vary significantly with age (P greater than 0.1). We also found no significant increase with age in the magnitude of the peak F response to oCRH (P greater than 0.2), although peak F responses occurred significantly earlier (P less than 0.03) in the older men. Basal plasma levels of DHEA decreased significantly with age (P less than 0.001), as did the magnitude of peak DHEA responses to endogenous ACTH rises (P less than 0.01). There was no alteration in the timing of the peak DHEA response with age (P greater than 0.7). We conclude that while ACTH and F responses to evening injections of oCRH are well maintained in healthy aging men, that of DHEA is discordantly decreased. The present findings are compatible with the hypotheses that there is a diminished sensitivity of ACTH secretion to negative feedback regulation by glucocorticoids in older men, and there is an ACTH-independent age-related diminution in adrenal androgen secretion.
影响因子：
4.8
作者：
C. Rivier;M. Brownstein;J. Spiess;J. Rivier;W. Vale
通讯作者：
C. Rivier;M. Brownstein;J. Spiess;J. Rivier;W. Vale
血浆促肾上腺皮质激素和皮质醇对静脉注射绵羊促肾上腺皮质激素释放激素的反应的昼夜变化。
DOI：
10.1210/jcem-61-2-273
发表时间：
1985
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
DeCherney,GS;DeBold,CR;Jackson,RV;SheldonJr,WR;Island,DP;Orth,DN
通讯作者：
Orth,DN