Plasma protein carbonyls and breast cancer risk in sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry.
Plasma protein carbonyls and breast cancer risk in sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry.
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乳腺癌家族登记处纽约站点的乳腺癌不一致的姐妹中的血浆蛋白羰基和乳腺癌风险。
DOI：
10.1158/0008-5472.can-08-3418
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发表时间：
2009
期刊：
影响因子：
11.2
通讯作者：
Santella,ReginaM
中科院分区：
文献类型：
--
作者：
Zipprich,Jennifer;Terry,MaryBeth;Liao,Yuyan;Agrawal,Meenakshi;Gurvich,Irina;Senie,Ruby;Santella,ReginaM
Reactive oxygen species are important in the pathogenesis of many diseases, including breast cancer. Several population-based case-control studies have shown that various biomarkers of oxidative stress are associated with an increase in breast cancer risk. We selected sisters discordant for breast cancer (n= 645) from the New York site of the Breast Cancer Family Registry to explore factors that contribute to variation in plasma protein carbonyls, and to determine whether this biomarker is associated with an increase in breast cancer risk among those with a family history. Late age at menarche, hormone replacement therapy use, and Hispanic race were significantly associated with lower plasma protein carbonyl levels in unaffected sisters. Plasma protein carbonyls were associated with an increase in breast cancer risk [Q2 odds ratio (OR), 1.4; 95% confidence interval (CI), 0.8–2.7; Q3 OR, 2.4; 95% CI, 1.1–4.9; Q4 OR, 1.9; 95% CI, 0.8–4.2], although not in a dose-dependent manner. These data suggest that oxidative damage is a risk factor for breast cancer in high-risk women. [Cancer Res 2009;69(7):2966–72]
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女性青春期期间的荷尔蒙事件与乳腺癌风险相关。
影响因子：
2.4
作者：
D. Apter
通讯作者：
D. Apter
激素替代疗法对绝经期妇女血液抗氧化酶的影响。
DOI：
--
发表时间：
2006
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
T. C. Unfer;G. Conterato;João C N da Silva;M. Duarte;T. Emanuelli
通讯作者：
T. Emanuelli
影响因子：
4.1
作者：
REZNICK, AZ;CROSS, CE;HALLIWELL, B
通讯作者：
HALLIWELL, B
白塞氏病秋水仙碱和维生素 E 治疗后血清羰基和丙二醛水平的变化。
影响因子：
--
作者：
O. Gulbahar;H. Adışen;C. Koca;A. Aricioglu;A. Gulekon
通讯作者：
A. Gulekon
影响因子：
11.2
作者：
B. Pignatelli;Chun-Qi Li;P. Boffetta;Qiping Chen;W. Ahrens;F. Nyberg;A. Mukeria;I. Brüske-Hohlfeld;C. Fortes;V. Constantinescu;H. Ischiropoulos;H. Ohshima
通讯作者：
B. Pignatelli;Chun-Qi Li;P. Boffetta;Qiping Chen;W. Ahrens;F. Nyberg;A. Mukeria;I. Brüske-Hohlfeld;C. Fortes;V. Constantinescu;H. Ischiropoulos;H. Ohshima