The Chemokine Receptor 5 Delta32 Polymorphism and Type 1 Diabetes, Behcet’s Disease, and Asthma: A Meta-analysis
The Chemokine Receptor 5 Delta32 Polymorphism and Type 1 Diabetes, Behcet’s Disease, and Asthma: A Meta-analysis
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趋化因子受体 5 Delta32 多态性与 1 型糖尿病、白塞病和哮喘：荟萃分析
作者：
G. Song;Jaehoon Kim;Y. Lee
目的：本研究的目的是确定功能性趋化因子受体 5 delta32 (CCR5-Δ32) 多态性是否与 1 型糖尿病 (T1D)、白塞氏病 (BD) 和哮喘的易感性相关。结果：14 项研究涵盖 9,656 例病例和 12,431 名对照，其中 6 项针对 T1D，5 项针对 BD，3 项针对哮喘，可用于荟萃分析。荟萃分析显示，T1D 与 CCR5-Δ32 等位基因之间存在显着负相关（比值比 [OR] = 0.854，95% 置信区间 [CI] = 0.800–0.912，p = 2.2 × 10−7）。按种族分层和对 Δ32Δ32 + Δ32W 基因型的分析表明，欧洲人中 CCR5-Δ32 等位基因与 T1D 之间存在显着负相关（OR = 0.857，95% CI = 0.802–0.915，p = 3.5 × 10−8； OR = 0.896，95% CI = 0.808–0.932，p = 9.3 × 10−6）。荟萃分析显示BD与Δ32Δ32 + Δ32W基因型呈正相关（OR = 1.403，95% CI = 1.008–1.954，p = 0.045）。按 HLA-B51 状态分层表明 CCR5-Δ32 等位基因与 HLA-B51 阳性 BD 之间存在关联，但与 HLA-B51 阴性 BD 无关（OR = 1.619，95% CI = 1.070–2.451，p = 0.023；OR = 1.036， 95% CI = 0.674–1.593，p = 0.872，分别）。未发现 CCR5-Δ32 多态性与哮喘之间存在关联。结论：这项荟萃分析表明，CCR5-Δ32 多态性是欧洲人 T1D 发展的保护因素，也是 HLA-B51 携带者 BD 的危险因素。然而，未发现 CCR5-Δ32 多态性与哮喘之间存在关联。
Objective: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to type 1 diabetes (T1D), Behcet’s disease (BD), and asthma. Results: Fourteen studies encompassing 9,656 cases and 12,431 controls, including 6 on T1D, 5 on BD, and 3 on asthma, were available for meta-analysis. The meta-analysis showed a significant negative association between T1D and the CCR5-Δ32 allele (odds ratio [OR] = 0.854, 95% confidence interval [CI] = 0.800–0.912, p = 2.2 × 10−7). Stratification by ethnicity and analysis of the Δ32Δ32 + Δ32W genotype indicated a significant negative association between the CCR5-Δ32 allele and T1D in Europeans (OR = 0.857, 95% CI = 0.802–0.915, p = 3.5 × 10−8; OR = 0.896, 95% CI = 0.808–0.932, p = 9.3 × 10−6, respectively). The meta-analysis showed a positive association between BD and the Δ32Δ32 + Δ32W genotype (OR = 1.403, 95% CI = 1.008–1.954, p = 0.045). Stratification by HLA-B51 status indicated an association between the CCR5-Δ32 allele and HLA-B51-positive BD, but not HLA-B51-negative BD (OR = 1.619, 95% CI = 1.070–2.451, p = 0.023; OR = 1.036, 95% CI = 0.674–1.593, p = 0.872, respectively). No association was found between the CCR5-Δ32 polymorphism and asthma. Conclusions: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism acts as a protective factor in T1D development in Europeans, and a risk factor for BD among HLA-B51 carriers. However, no association was found between the CCR5-Δ32 polymorphism and asthma.
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趋化因子受体等位基因多态性：与艾滋病毒耐药性和疾病进展的关系。
DOI：
10.1006/smim.1998.0132
发表时间：
1998
期刊：
Seminars in immunology.
影响因子：
--
作者：
Paxton,WA;Kang,S
通讯作者：
Kang,S
影响因子：
--
作者：
Lee, YH;Witte, T;Sestak, AL
通讯作者：
Sestak, AL
CCR5 delta 32 多态性 (rs333) 与哥伦比亚人的干燥综合征或 1 型糖尿病无关。
DOI：
10.1016/j.clim.2013.05.010
发表时间：
2013
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Maier-Moore,JacenS;Cañas,CarlosA;Tobón,Gabriel;Arango,Alvaro;Anaya,Juan-Manuel;Scofield,RHal
通讯作者：
Scofield,RHal
影响因子：
7.7
作者：
Mlynarski, WM;Placha, GP;Krolewski, AS
通讯作者：
Krolewski, AS