Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?
Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?
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DOI：
10.1111/j.1582-4934.2009.00645.x
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发表时间：
2009-03
影响因子：
5.3
通讯作者：
Moore PK
中科院分区：
文献类型：
--
作者：
Whiteman M;Moore PK
硫化氢 (H2S) 是一种众所周知的刺激性有毒气体，最近被证明是在人体中通过至少两种不同的酶由氨基酸胱硫醚、同型半胱氨酸和半胱氨酸合成的；胱硫醚-γ-裂解酶和胱硫醚-β-合酶。在过去的几年中，H2S 已成为心血管系统中一种新型且日益重要的介质，但事实证明，描述 H2S 的精确生理学和病理生理学是复杂的，并且难以通过报告的细胞类型、组织类型和动物物种的不同发现来阐明。因此，在这篇综述中，我们总结了 H2S 调节血压和心脏功能的机制，讨论了文献中报道的机制差异以及 H2S 的治疗潜力。我们还研究了生物体液中 H2S 的检测方法、H2S 的去除过程，并讨论了心血管病理学的人和动物模型中报告的 H2S 血液水平。我们还强调了 H2S 与一氧化氮在调节健康和疾病心血管功能方面的复杂相互作用。
Hydrogen sulfide (H2S) is a well known and pungent toxic gas that has recently been shown to be synthesised in man from the amino acids cystathionine, homocysteine and cysteine by at least two distinct enzymes; cystathionine-γ-lyase and cystathionine-β-synthase. In the past few years, H2S has emerged as a novel and increasingly important mediator in the cardiovascular system but delineating the precise physiology and pathophysiology of H2S is proving to be complex and difficult to unravel with disparate findings reported with cell types, tissue types and animal species reported. Therefore, in this review we summarize the mechanisms by which H2S has been proposed to regulate blood pressure and cardiac function, discuss the mechanistic discrepancies reported in the literature as well as the therapeutic potential of H2S. We also examine the methods of H2S detection in biological fluids, processes for H2S removal and discuss the reported blood levels of H2S in man and animal models of cardiovascular pathology. We also highlight the complex interaction of H2S with nitric oxide in regulating cardiovascular function in health and disease.
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影响因子：
5.3
作者：
Fu, WY;Dudman, NPB;Wang, XL
通讯作者：
Wang, XL
影响因子：
9.6
作者：
Chen, YH;Yao, WZ;Tang, CS
通讯作者：
Tang, CS
DOI：
10.1073/pnas.0705891104
发表时间：
2007-09-25
影响因子：
11.1
作者：
Elrod, John W.;Calvert, John W.;Lefer, David J.
通讯作者：
Lefer, David J.
原发性高血压儿童内源性同型半胱氨酸与硫化氢代谢途径失衡
影响因子：
6.1
作者：
Chen Li;Ingrid, Sumou;Du Jun-bao
通讯作者：
Du Jun-bao
DOI：
10.1152/ajpregu.00419.2003
发表时间：
2004-04-01
影响因子：
2.8
作者：
Dombkowski, RA;Russell, MJ;Olson, KR
通讯作者：
Olson, KR