Inhibition of Endogenous Hydrogen Sulfide Generation is Associated with Homocysteine-Induced Neurotoxicity: Role of ERK1/2 Activation

Inhibition of Endogenous Hydrogen Sulfide Generation is Associated with Homocysteine-Induced Neurotoxicity: Role of ERK1/2 Activation
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抑制内源性硫化氢生成与同型半胱氨酸诱导的神经毒性相关:ERK1/2 激活的作用

DOI:
10.1007/s12031-010-9477-z
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发表时间:
2011-09
影响因子:
3.1
通讯作者:
Wang, Chun-Yan
Wang, Chun-Yan
中科院分区:
医学4区
文献类型:
--
作者:
Ren, Yan-Kai;Fang, Heng-Rong;Zhuang, Yuan-Yuan;Wang, Chun-Yan

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在阿尔茨海默病(AD)患者的脑中观察到升高的同型半胱氨酸和降低的硫化氢(H2S)。活性氧(ROS)的过度产生有助于同型半胱氨酸的神经毒性;然而,H2S是一种内源性的,
Both elevated homocysteine and decreased hydrogen sulfide (H2S) are observed in the brains of Alzheimer’s disease (AD) patients. Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of homocysteine; however, H2S is an endogenous a
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