Multiple sclerosis affects the frequency content in the vertical ground reaction forces during walking.
Multiple sclerosis affects the frequency content in the vertical ground reaction forces during walking.
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DOI：
10.1016/j.clinbiomech.2010.09.021
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Stergiou N
中科院分区：
文献类型：
--
作者：
Wurdeman SR;Huisinga JM;Filipi M;Stergiou N
多发性硬化症是一种进行性神经系统疾病，导致步态障碍的发生率很高。探索步行过程中产生的地面反作用力的频率内容可能会为多发性硬化症患者的步态提供更多的见解，从而可能导致特定的鉴别诊断工具。这项研究的目的是调查这些力量在频率内容上的差异，努力为改善这种疾病的临床治疗做出贡献。18名患者和18名健康对照走过一条10米长的人行道。利用快速傅立叶变换在频域中计算了步态站立阶段产生的前后和垂直地面反作用力。T检验用于比较患者和健康对照组之间的中位频率、99.5%频率和频带宽度，也用于比较轻度和中度重度患者之间的差异。多发性硬化症患者垂直地面反作用力的99.5%频率(p=0.006)和中位数频率(p<；0.001)显著降低。前后反作用力频率含量无明显差异。轻度和中度患者之间无差异。较低的频率含量表明重心的垂直振荡较小。严重程度之间缺乏差异可能意味着在目前确定的诊断时间表之前存在差异。对频率成分的分析可能有助于对这种衰弱疾病的早期诊断评估。
Multiple sclerosis is a progressive neurological disease that results in a high incident of gait disturbance. Exploring the frequency content of the ground reaction forces generated during walking may provide additional insights to gait in patients with multiple sclerosis that could lead to specific tools for differential diagnosis. The purpose of this study was to investigate differences in the frequency content of these forces in an effort to contribute to improved clinical management of this disease. Eighteen patients and eighteen healthy controls walked across a 10 meter long walkway. The anterior-posterior and vertical ground reaction forces generated during the stance phase of gait were evaluated in the frequency domain using fast Fourier transformation. T-tests were utilized for comparison of median frequency, the 99.5% frequency, and the frequency bandwidth between patients and healthy controls and also for comparisons between patients with mild and moderate severity. Patients with multiple sclerosis had significantly lower 99.5% frequency (p =0.006) and median frequency (p <0.001) in the vertical ground reaction force. No differences were found in the anterior-posterior reaction force frequency content. There were no differences between patients with mild and moderate severity. The lower frequency content suggests lesser vertical oscillation of the center of gravity. Lack of differences between severities may suggest presence of differences prior to currently established diagnosis timelines. Analysis of the frequency content may potentially serve to provide earlier diagnostic assessment of this debilitating disease.
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