Synaptogenesis in the primary visual cortex of the tree shrew (Tupaia belangeri)
Synaptogenesis in the primary visual cortex of the tree shrew (Tupaia belangeri)
复制标题
树鼩（Tupaia belangeri）初级视觉皮层的突触发生
DOI：
10.1002/cne.903080313
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
G. Rager
中科院分区：
文献类型：
--
作者：
A. Ungersböck;R. Kretz;G. Rager
树鼩的初级视觉皮层的特点是缺乏眼优势柱。两只眼睛代表在第 3 和第 4 层的亚层中。在一项使用跨神经元传输的早期研究中，我们观察到来自两只眼睛的膝状传入神经最初并不重叠，然后分离到相应的亚层中。最终的分布模式在产后早期就已经可以观察到。由于传入末端分支的分离和消除似乎没有发生，我们想研究是否可以像其他几种动物一样观察到突触的过度产生。我们使用电子显微镜检查了从 P5 到成熟的 3B、3C、4A 和 4B 层，这些层通过外侧膝状核接收来自视网膜的传入信号。在成年动物代表中央视觉的区域切除脑组织。然后，我们确定了 P5、P15、P19、P23、P31 和 P42 年龄以及成年动物 (AD) 四个亚层中每一个亚层每 100 μm2 神经纤维的突触密度。在确定神经纤维时，我们测量了两个附加隔室的大小，即由核周和血管组成的隔室。我们以更高的分辨率确定了每个亚层和每个发育阶段的灰色 I 型和 II 型突触的比例。
The primary visual cortex of the tree shrew is characterized by the lack of ocular dominance columns. The two eyes are represented in sublayers of laminae 3 and 4. In an earlier study using the transneuronal transport we observed that the geniculate afferents from the two eyes do not initially overlap and then segregate into their appropriate sublaminae. The final distribution pattern can already be observed during the early postnatal period. Since segregation and elimination of afferent terminal branches do not seem to take place, we wanted to investigate whether or not an overproduction of synapses can be observed as in several other animals. We examined layers 3B, 3C, 4A, and 4B, which receive afferents from the retina via the lateral geniculate nucleus, from P5 to maturity by using the electron microscope. The brain tissue was excised in the region where the central vision is represented in adult animals. Then we determined the density of synapses per 100 μm2 neuropil for each of the four sublayers at the ages P5, P15, P19, P23, P31, and P42 and in the adult animal (AD). In determining the neuropil we measured the size of two additional compartments, i.e., the compartments consisting of perikarya and of blood vessels. At a higher resolution we determined the fraction of Gray type I and type II synapses in each sublamina and in each developmental stage.
影响因子：
56.9
作者：
RAKIC, P;BOURGEOIS, JP;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
DOI：
10.1016/0165-3806(89)90124-7
发表时间：
1989-11
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Nada Zecevic;Jean-Pierre Bourgeois;P. Rakic
通讯作者：
Nada Zecevic;Jean-Pierre Bourgeois;P. Rakic