Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors.
Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors.
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髓样C型凝集素受体自我和非自身感测后的信号传导多功能性。
DOI：
10.1016/j.imbio.2014.09.013
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发表时间：
2015-02
期刊：
影响因子：
2.8
通讯作者：
Sancho, David
中科院分区：
文献类型：
--
作者：
Iborra, Salvador;Sancho, David
在髓系免疫受体中，C型凝集素受体（CLRs）具有显著的感知多种自身和非自身配体的能力。CLR与不同信号转导模块的偶联不仅受受体的影响，而且受配体的性质、密度和结构的影响，这可以影响受体内化和运输到不同细胞内区室的速率。了解自身和非自身配体的多样性如何触发差异化的信号传导和功能是一个迷人的生物学挑战。非自身配体通常促进炎症和免疫，而自身配体经常参与通讯和耐受。但是病原体可以模仿自我抑制信号以逃避免疫监视，并且内源性配体可以通过CLR促进病原体的感测。在这篇综述中，我们调查的复杂性和灵活性的功能结果中发现的髓样CLRs，这不仅是基于它们不同的细胞内基序，但也是由物理性质，亲和力和亲和力的配体。
Among myeloid immune receptors, C-type lectin receptors (CLRs) have a remarkable capacity to sense a variety of self and non-self ligands. The coupling of CLRs to different signal transduction modules is influenced not only by the receptor, but also by the nature, density and architecture of the ligand, which can affect the rate of receptor internalization and trafficking to diverse intracellular compartments. Understanding how the variety of self and non-self ligands triggers differential CLR signalling and function presents a fascinating biological challenge. Non-self ligands usually promote inflammation and immunity, whereas self ligands are frequently involved in communication and tolerance. But pathogens can mimic self-inhibitory signals to escape immune surveillance, and endogenous ligands can contribute to the sensing of pathogens through CLRs. In this review, we survey the complexity and flexibility in functional outcome found in the myeloid CLRs, which is not only based on their differing intracellular motifs, but is also conditioned by the physical nature, affinity and avidity of the ligand.
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影响因子：
64.5
作者：
Geijtenbeek, TBH;Torensma, R;Figdor, CG
通讯作者：
Figdor, CG
影响因子：
15.3
作者：
Geijtenbeek, TBH;van Vliet, SJ;Koppel, EA;Sanchez-Hernandez, M;Vandenbroucke-Grauls, CMJE;Appelmelk, B;van Kooyk, Y
通讯作者：
van Kooyk, Y
DOI：
10.1084/jem.20100793
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barrett NA;Rahman OM;Fernandez JM;Parsons MW;Xing W;Austen KF;Kanaoka Y
通讯作者：
Kanaoka Y
影响因子：
30.5
作者：
Gringhuis, Sonja I.;den Dunnen, Jeroen;Geijtenbeek, Teunis B. H.
通讯作者：
Geijtenbeek, Teunis B. H.
影响因子：
8.7
作者：
Hamerman JA;Ni M;Killebrew JR;Chu CL;Lowell CA
通讯作者：
Lowell CA