Paying the Toll in Nuclear Reprogramming.
Paying the Toll in Nuclear Reprogramming.
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DOI：
10.3389/fcell.2017.00070
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发表时间：
2017
影响因子：
5.5
通讯作者：
Sayed N
中科院分区：
文献类型：
--
作者：
Liu C;Himmati F;Sayed N
The ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by causing global changes in the expression and activity of epigenetic modifiers. Here we discuss, in a comprehensive manner, the recent studies on the role of innate immunity in nuclear reprogramming and transdifferentiation, the underlying mechanisms, and its role in regenerative medicine.
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影响因子：
17.1
作者：
Matsa E;Burridge PW;Wu JC
通讯作者：
Wu JC
DOI：
10.1073/pnas.1300290110
发表时间：
2013-06-04
影响因子：
11.1
作者：
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通讯作者：
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通讯作者：
Rafii S
影响因子：
64.8
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影响因子：
64.5
作者：
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通讯作者：
Cooke JP