Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan.
Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan.
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DOI：
10.1186/s12885-015-1308-8
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发表时间：
2015-04-12
期刊：
影响因子：
3.8
通讯作者：
Shibuya K
中科院分区：
文献类型：
--
作者：
Okubo Y;Nemoto T;Wakayama M;Tochigi N;Shinozaki M;Ishiwatari T;Aki K;Tsuchiya M;Aoyama H;Katsura K;Fujii T;Nishigami T;Yokose T;Ohkura Y;Shibuya K
节细胞性副神经节瘤是一种极为罕见的良性肿瘤，通常发生在十二指肠的第二部分。由于GP既无明显的核分裂活性，也无Ki-67免疫反应，常被误诊为神经内分泌瘤(Net)G1(类癌)。然而，GP患者的预后可能比Net G1患者更好。这一事实强调了区分GP和Net G1的重要性，但由于GP的罕见，很少有关于GP的流行病学和组织病理学的报道。为了容易地区分GP和Net G1，我们进行了一项多机构的回顾性研究，分析了该肿瘤的形态计量学和免疫组织化学特征。由于在我们研究所只能发现有限数量的GP患者，我们在日本进行了一项多机构的GP回顾研究，该研究得到了我们医学研究所伦理委员会的批准。获得的组织切片进行了详细的形态测量和免疫组织化学分析。此外，为了更容易地区分GP和Net G1，对免疫组织化学结果进行了比较。在12例十二指肠GP的检查中，我们发现GP的上皮样细胞对孕激素受体和胰多肽呈阳性反应，而Net G1的肿瘤细胞对两者均呈完全阴性反应。此外，尽管GP被认为是一种极其罕见的Net，但我们发现我们研究所的10名十二指肠Net G1患者中有4人(40.0%)实际上患有Gp。虽然GP被认为是一种罕见的网，但我们的结果表明，它在十二指肠网中占有相当大的比例。此外，确认孕激素受体和胰多肽的免疫反应性有助于区分GP和Net G1。
Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor). However, patients with GP may have a better prognosis than patients with NET G1. This fact emphasizes the importance of differentiating GP from NET G1, but few studies have reported the epidemiology and histopathology of GP because of its rarity. To differentiate GP from NET G1 with ease, we conducted a multi-institutional retrospective study analyzing the morphometric and immunohistochemical features of this tumor. Since only a limited number of patients with GP could be identified in our institute, we conducted a multi-institutional retrospective study of GP in Japan, which was approved by the Ethics Committee of our medical institute. The obtained tissue sections underwent detailed morphometric and immunohistochemical analyses. Additionally, to differentiate GP from NET G1 with ease, immunohistochemical findings were compared. In our examination of 12 cases of duodenal GP, we found that epithelioid cells of GP exhibited positive reactivity for progesterone receptor and pancreatic polypeptide, whereas tumor cells of NET G1 were completely negative reactivity for both. Additionally, although GP is considered to be an extremely rare NET, we found that four (40.0%) of the ten patients at our institute with duodenal NET G1 actually had GP. Although GP is regarded as a rare NET, our results suggest that it accounts for a substantial percentage of duodenal NETs. Additionally, confirmation of immunoreactivity for progesterone receptor and pancreatic polypeptide can assist in differentiating GP from NET G1.
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影响因子：
3.8
作者：
Okubo Y;Wakayama M;Nemoto T;Kitahara K;Nakayama H;Shibuya K;Yokose T;Yamada M;Shimodaira K;Sasai D;Ishiwatari T;Tsuchiya M;Hiruta N
通讯作者：
Hiruta N
影响因子：
6.2
作者：
Pape, Ulrich-Frank;Jann, Henning;Wiedenmann, Bertram
通讯作者：
Wiedenmann, Bertram
影响因子：
6
作者：
Lubensky, IA;Pack, S;Zhuang, ZP
通讯作者：
Zhuang, ZP
DOI：
10.1007/bf00704306
发表时间：
1985-01-01
期刊：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
影响因子：
--
作者：
KAWAGUCHI, K;TAKIZAWA, T;GOSEKI, N
通讯作者：
GOSEKI, N
影响因子：
1.8
作者：
Ohtsuki, Yuji;Watanabe, Ryohei;Furihata, Mutsuo
通讯作者：
Furihata, Mutsuo