Familial associations of Alzheimer disease and essential tremor with Parkinson disease.
Familial associations of Alzheimer disease and essential tremor with Parkinson disease.
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DOI：
10.1111/j.1468-1331.2010.02974.x
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发表时间：
2010-06-01
影响因子：
5.1
通讯作者：
Ritz B
中科院分区：
文献类型：
--
作者：
Costello S;Bordelon Y;Bronstein J;Ritz B
我们构建了一个队列的参与者的一级亲属在人口为基础的帕金森病（PD）的病例对照研究，并比较阿尔茨海默病（AD）和原发性震颤（ET）的发生在PD病例和对照组的亲属。我们依靠先证者访谈来评估372名先证者的家族史，这些先证者由运动障碍专家证实，404名对照者来自加州的三个农村县。总体而言，2980例PD病例的一级亲属与2981例对照组亲属相比，AD的风险并未增加。但较年轻发病的PD患者（<=60岁）的亲属接受AD诊断的可能性是其3倍（HR：2.86; 95%CI：1.44，5.71）。我们的数据还表明，PD先证者的一些亲属接受ET诊断的风险可能略有增加，尤其是震颤显性病例的亲属（HR：1.69; 95%CI 0.99，2.88）、年轻发病病例的亲属（HR：2.03; 95%CI 0.93，4.44）和男性亲属（HR：2.31; 95%CI 1.13，4.73）。此外，当被诊断患有ET时，病例组的父亲比对照组的父亲年轻近15岁。敏感性分析结果稳定。我们的研究表明，家族易感性AD的一级亲属中的年轻发病的PD病例。
We constructed a cohort of first degree relatives of participants in a population-based case-control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls. We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Overall, for the 2980 first degree relatives of PD cases the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (<=60 years of age) were three times more likely to have received an AD diagnosis (HR: 2.86; 95%CI: 1.44, 5.71). Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. Our study suggests a familial susceptibility to AD among first degree relatives of younger onset PD cases.
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影响因子：
9.9
作者：
Louis, ED;Levy, G;Marder, K
通讯作者：
Marder, K
影响因子：
--
作者：
Rocca, Walter A.;Bower, James H.;Maraganore, Demetrius M.
通讯作者：
Maraganore, Demetrius M.
DOI：
10.1073/pnas.92.20.9141
发表时间：
1995-09-26
影响因子：
11.1
作者：
YOSHIMOTO, M;IWAI, A;SAITOH, T
通讯作者：
SAITOH, T
影响因子：
2.1
作者：
Ellis, RJ;Caligiuri, M;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
9.9
作者：
Benito-Leon, Julian;Louis, Elan D.;Bermejo-Pareja, Felix
通讯作者：
Bermejo-Pareja, Felix