Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus)
Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus)
复制标题
慢性消耗性疾病朊病毒向松鼠猴（Saimiri sciureus）的种间传播
作者：
R. Marsh;A. Kincaid;R. Bessen;Jason C. Bartz
慢性消耗性疾病（CWD）是一种新发现的鹿和麋鹿朊病毒病。暴露于受慢性消耗病感染的组织后，慢性消耗病传播给人类的风险尚不清楚。为了评估非人灵长类动物对慢性消耗病的易感性，两只松鼠猴接种了来自慢性消耗病感染的黑尾鹿的脑组织。接种CWD的松鼠猴发展为进行性神经退行性疾病，并在感染后31和34个月被安乐死。感染CWD的松鼠猴的脑组织含有异常的朊病毒蛋白亚型PrP-res，并显示海绵状变性。这是首次报道慢性消耗病传播给灵长类动物。
ABSTRACT Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.
影响因子：
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作者：
Belay, ED;Gambetti, P;Nichols, CR
通讯作者：
Nichols, CR