SARS-CoV-2: An Update on Genomics, Risk Assessment, Potential Therapeutics and Vaccine Development.
SARS-CoV-2: An Update on Genomics, Risk Assessment, Potential Therapeutics and Vaccine Development.
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DOI：
10.3390/ijerph18041626
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发表时间：
2021-02-08
影响因子：
--
通讯作者：
Tahir Ul Qamar M
中科院分区：
文献类型：
--
作者：
Mehmood I;Ijaz M;Ahmad S;Ahmed T;Bari A;Abro A;Allemailem KS;Almatroudi A;Tahir Ul Qamar M
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 对公共健康构成巨大威胁，是致命冠状病毒病 (COVID-19) 的致病病原体。它已传播到 200 多个国家，感染了全球数百万人。尽管 SARS-CoV-2 与之前报道的 SARS-CoV 和 MERS-CoV 具有结构/基因组相似性，但其基因组中的特定突变使其成为一种新型病毒。现有的治疗策略未能控制这种病毒。尽管有严格的标准操作程序 (SOP)，SARS-CoV-2 仍已在全球范围内传播，并且正在逐渐变异。需要勤奋努力、特殊护理和提高认识，以减少易感人群，特别是老年人、儿童和医护人员之间的传播。在这篇综述中，我们重点介绍了 SARS-CoV-2 的基本基因组组织和结构。讨论了其传播动态、症状和相关危险因素。本综述还介绍了其基因组中发现的最新突变、正在使用的潜在治疗方案，以及针对 COVID-19 疫苗开发工作的简要说明。这项工作不仅将帮助读者了解致命的 SARS-CoV-2 病毒，还将为研究人员的研究工作提供最新信息。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great threat to public health, being a causative pathogen of a deadly coronavirus disease (COVID-19). It has spread to more than 200 countries and infected millions of individuals globally. Although SARS-CoV-2 has structural/genomic similarities with the previously reported SARS-CoV and MERS-CoV, the specific mutations in its genome make it a novel virus. Available therapeutic strategies failed to control this virus. Despite strict standard operating procedures (SOPs), SARS-CoV-2 has spread globally and it is mutating gradually as well. Diligent efforts, special care, and awareness are needed to reduce transmission among susceptible masses particularly elder people, children, and health care workers. In this review, we highlighted the basic genome organization and structure of SARS-CoV-2. Its transmission dynamics, symptoms, and associated risk factors are discussed. This review also presents the latest mutations identified in its genome, the potential therapeutic options being used, and a brief explanation of vaccine development efforts against COVID-19. The effort will not only help readers to understand the deadly SARS-CoV-2 virus but also provide updated information to researchers for their research work.
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影响因子：
10.8
作者：
Blakney, Anna K.;McKay, Paul F.;Shattock, Robin J.
通讯作者：
Shattock, Robin J.
影响因子：
2.9
作者：
Cao Y;Hiyoshi A;Montgomery S
通讯作者：
Montgomery S
影响因子：
7.6
作者：
Beigel, John H.;Nam, Hannah H.;Sims, Amy C.
通讯作者：
Sims, Amy C.
影响因子：
4.3
作者：
Bull, James J.;Nuismer, Scott L.;Antia, Rustom
通讯作者：
Antia, Rustom
DOI：
10.1007/s43440-020-00176-1
发表时间：
2020-12
期刊：
Pharmacological reports : PR
影响因子：
--
作者：
Abobaker A;Alzwi A;Alraied AHA
通讯作者：
Alraied AHA