Overview of the possible role of vitamin C in management of COVID-19.
Overview of the possible role of vitamin C in management of COVID-19.
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DOI：
10.1007/s43440-020-00176-1
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Alraied AHA
中科院分区：
文献类型：
--
作者：
Abobaker A;Alzwi A;Alraied AHA
2019年冠状病毒病(新冠肺炎)的管理主要是支持性的，因为到目前为止还没有有效的抗病毒治疗，除了已被食品和药物管理局批准用于治疗新冠肺炎的瑞希韦或疫苗。作为新冠肺炎支持性管理的一部分，补充维生素和矿物质等微量营养素越来越受到人们的关注。在感染的急性期，由于代谢需求增加，血清和白细胞中的维生素C水平会耗尽。大剂量维生素C补充剂有助于使血清和白细胞的维生素C水平正常化。维生素C具有多种药理作用，具有抗病毒、抗氧化、抗炎和免疫调节等作用，使其成为治疗新冠肺炎的潜在选择。中国和美国使用大剂量静脉注射维生素C治疗新冠肺炎取得了良好的效果。没有关于短期使用大剂量维生素C的不良反应的报道，鉴于维生素C是廉价、可获得、安全的药物，在管理病毒感染和危重患者方面具有有益效果的事实在先前的临床试验中得到了报道，因此将其添加到新冠肺炎管理协议中是明智的，尤其是如果目前正在进行的测试维生素C在管理新冠肺炎中的效果的临床试验显示出阳性结果的话。
The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results.
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影响因子：
7.6
作者：
CINATL, J;CINATL, J;DOERR, HW
通讯作者：
DOERR, HW
影响因子：
5.9
作者：
Carr AC;Maggini S
通讯作者：
Maggini S
抗氧化剂治疗可改善呼吸道合胞病毒引发的疾病和肺部炎症
DOI：
10.1164/rccm.200603-319oc
发表时间：
2006-12-15
影响因子：
24.7
作者：
Castro, Shawn Monique;Guerrero-Plata, Antonieta;Casola, Antonella
通讯作者：
Casola, Antonella
DOI：
10.1186/s13054-017-1891-y
发表时间：
2017-12-11
期刊：
Critical care (London, England)
影响因子：
--
作者：
Carr AC;Rosengrave PC;Bayer S;Chambers S;Mehrtens J;Shaw GM
通讯作者：
Shaw GM
影响因子：
5.9
作者：
Chen, Liang;Hu, Chun;Du, Jun
通讯作者：
Du, Jun