Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review.
Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review.
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DOI：
10.1590/1980-57642021dn15-020002
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Dos Santos JCC
中科院分区：
文献类型：
--
作者：
Campos EMN;Rodrigues LD;Oliveira LF;Dos Santos JCC
考虑到单纯疱疹病毒(HSV-1)污染的多种机制及其对神经系统的广泛侵袭潜力，建立了终生潜伏感染。在多重应激源的影响下，受感染的成人个体可能容易被病毒重新激活，特别是对于免疫功能低下的患者。这引导了大脑皮层的一系列神经炎性事件，最终导致脑炎和细胞毒性/血管源性脑水肿，这种情况很少见。对这些过程的研究总结为临床演变为认知障碍和痴呆症提供了一种解释，尽管尚未完全阐明。此外，认识当前世界范围内的痴呆症和认知缺陷具有极其重要的意义。这篇文献综述的目的是阐明关于HSV-1感染的病理生理学方面的现有数据，并描述所涉及的疾病的临床全貌。
Considering the variety of mechanisms of Herpes simplex virus (HSV-1) contamination and its broad invasive potential of the nervous system, a life-long latent infection is established. Infected adult individuals may be susceptible to viral reactivation when under the influence of multiple stressors, especially regarding immunocompromised patients. This guides a series of neuroinflammatory events on the cerebral cortex, culminating, rarely, in encephalitis and cytotoxic / vasogenic brain edema. A sum of studies of such processes provides an explanation, even though not yet completely clarified, on how the clinical evolution to cognitive impairment and dementia might be enabled. In addition, it is of extreme importance to recognize the current dementia and cognitive deficit worldwide panorama. The aim of this literature review is to elucidate the available data upon the pathophysiology of HSV-1 infection as well as to describe the clinical panorama of the referred afflictions.
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