Sickle cell disease and ventricular myocardial strain: A systematic review.

Sickle cell disease and ventricular myocardial strain: A systematic review.
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镰状细胞病和心室心肌应变:系统综述。

DOI:
10.1002/pbc.28973
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发表时间:
2021-06
影响因子:
3.2
通讯作者:
--
中科院分区:
医学3区
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--
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心脏病是镰状细胞病(SCD)的主要死亡原因。心脏异常从童年开始,在一生中逐渐发展。右室和左室(RV,LV)心肌应变是收缩功能障碍的早期标志,但在SCD患者中尚未得到很好的研究。这篇综述的目的是:1)确定所有已发表的评估室性心肌劳损的研究,2)总结它们的价值,3)将结果与对照研究结果进行比较。从四个电子数据库-Medline、Embase、Scope us和Web of Science的搜索结果-确定42篇潜在文章,其中17篇符合纳入标准。已评估的研究表明,与对照组相比,SCD患者的右室和左室心肌应变通常是异常的,尽管射血/缩短分数正常。在这一人群中,心肌应变的评估并不一致,任何时候进行超声心动图都应该考虑心肌应变。
Cardiac disease is the primary cause of death in sickle cell disease (SCD). Cardiac abnormalities begin in childhood and progress throughout life. Right and left ventricular (RV, LV) myocardial strain are early markers of systolic dysfunction but are not well investigated among individuals with SCD. The objectives of this review were to 1) identify all published studiesthat have evaluatedventricular myocardial strain, 2) summarize their values, and 3) compare findings with those obtained from controls.From search results of four electronic databases—Medline, Embase, Scopus, and Web of Science—42 potential articles were identified, and 17 met eligibility criteria for inclusion. Theevaluated studies demonstrate thatRV and LV myocardial strain are generally abnormal in individuals with SCD compared with controls, despite having normal ejection/shortening fraction.Myocardial strain has been inconsistently evaluated in this population and should be considered any time an echocardiogram is performed.
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