Histological type and marker expression of the primary tumour compared with its local recurrence after breast-conserving therapy for ductal carcinoma in situ.
Histological type and marker expression of the primary tumour compared with its local recurrence after breast-conserving therapy for ductal carcinoma in situ.
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DOI：
10.1054/bjoc.2000.1618
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发表时间：
2001-02
影响因子：
8.8
通讯作者：
van de Vijver MJ
中科院分区：
文献类型：
--
作者：
Bijker N;Peterse JL;Duchateau L;Robanus-Maandag EC;Bosch CA;Duval C;Pilotti S;van de Vijver MJ
我们研究了乳腺原发性导管原位癌（DCIS）及其保乳治疗（BCT）后局部复发的组织学特征和标志物表达。在EORTC试验10853（广泛局部切除与切除加放疗）中随机分配并发生局部复发的患者被确定。对116例病例进行了组织学检查;对71例病例进行了雌激素和孕激素受体状态以及HER 2/ neu和p53过表达评估。比较原发性DCIS和浸润性或非浸润性复发，在62%中发现一致的组织学，在63%中发现相同的标记物表达。虽然11%的复发癌发生在远离原发性DCIS的地方，但几乎所有这些复发癌都显示出相同的组织学和免疫组化特征。5例患者在低分化DCIS后发展为高分化DCIS或I级浸润癌。虽然这些复发与原发性DCIS发生在同一象限，但它们可被视为第二原发性肿瘤。仅4例患者在高分化DCIS后发展为低分化DCIS或III级浸润癌。我们的结论是，在大多数情况下，原发性DCIS及其局部复发与组织学或标记物表达相关，表明局部复发通常反映了残留DCIS的生长;分化良好的DCIS向分化不良的DCIS或III级浸润性癌的进展是一个不常见的事件。© 2001年癌症研究运动http://www.bjcancer.com
We have investigated primary ductal carcinomas in situ (DCIS) of the breast and their local recurrences after breast-conserving therapy (BCT) for histological characteristics and marker expression. Patients who were randomized in the EORTC trial 10853 (wide local excision versus excision plus radiotherapy) and who developed a local recurrence were identified. Histology was reviewed for 116 cases; oestrogen and progesterone receptor status, and HER2/ neu and p53 overexpression were assessed for 71 cases. Comparing the primary DCIS and the invasive or non-invasive recurrence, concordant histology was found in 62%, and identical marker expression in 63%. Although 11% of the recurrences developed at a distance from the primary DCIS, nearly all these showed the same histological and immunohistochemical profile. 5 patients developed well-differentiated DCIS or grade I invasive carcinoma after poorly differentiated DCIS. Although these recurrences occurred in the same quadrant as the primary DCIS, they may be considered as second primary tumours. Only 4 patients developed poorly differentiated DCIS or grade III invasive carcinoma after well differentiated DCIS. We conclude that in most cases the primary DCIS and its local recurrence are related histologically or by marker expression, suggesting that local recurrence usually reflects outgrowth of residual DCIS; progression of well differentiated DCIS towards poorly differentiated DCIS or grade III invasive carcinoma is a non-frequent event. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
158.5
作者：
VANDEVIJVER, MJ;PETERSE, JL;NUSSE, R
通讯作者：
NUSSE, R
影响因子：
3.3
作者：
Mack, L;Kerkvliet, N;OMalley, FP
通讯作者：
OMalley, FP
影响因子：
120.7
作者：
Ernster, VL;Barclay, J;Henderson, IC
通讯作者：
Henderson, IC
影响因子：
168.9
作者：
Julien, JP;Bijker, N;Van Dongen, JA
通讯作者：
Van Dongen, JA
影响因子：
10.3
作者：
Waldman, FM;DeVries, S;Ljung, BM
通讯作者：
Ljung, BM