Macrophages: master regulators of inflammation and fibrosis.
Macrophages: master regulators of inflammation and fibrosis.
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DOI：
10.1055/s-0030-1255354
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发表时间：
2010-08
影响因子：
4.2
通讯作者：
Barron L
中科院分区：
文献类型：
--
作者：
Wynn TA;Barron L
发现巨噬细胞与产生胶原的肌成纤维细胞非常接近，并且无可争议地在纤维化中起关键作用。它们产生直接激活成纤维细胞的促纤维化介质，包括转化生长因子-β1和血小板衍生生长因子，并通过调节各种基质金属蛋白酶和基质金属蛋白酶组织抑制剂的平衡来控制细胞外基质周转。巨噬细胞还通过分泌趋化因子来募集成纤维细胞和其他炎性细胞来调节纤维发生。由于它们具有促纤维化和抗纤维化能力的潜力，以及它们调节驻留和募集的肌成纤维细胞活化的能力，巨噬细胞及其表达的因子被整合到纤维化过程的所有阶段中。这些不同的，有时是相反的，功能可以由不同的巨噬细胞亚群执行，其识别是纤维化研究的一个日益增长的焦点。虽然胶原分泌肌成纤维细胞曾经被认为是纤维化的主要“生产者”，但本文将阐述巨噬细胞如何作为纤维化的主要“调节者”发挥作用。
Macrophages are found in close proximity with collagen-producing myofibroblasts and indisputably play a key role in fibrosis. They produce profibrotic mediators that directly activate fibroblasts, including transforming growth factor-β1 and platelet-derived growth factor, and control extracellular matrix turnover by regulating the balance of various matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases. Macrophages also regulate fibrogenesis by secreting chemokines that recruit fibroblasts and other inflammatory cells. With their potential to act in both a pro- and antifibrotic capacity, as well as their ability to regulate the activation of resident and recruited myofibroblasts, macrophages and the factors they express are integrated into all stages of the fibrotic process. These various, and sometimes opposing, functions may be performed by distinct macrophage subpopulations, the identification of which is a growing focus of fibrosis research. Although collagen-secreting myofibroblasts once were thought of as the master “producers” of fibrosis, this review will illustrate how macrophages function as the master “regulators” of fibrosis.
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影响因子：
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作者：
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发表时间：
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影响因子：
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