Ectopic otoconial formation in the lagena of the pigeon inner ear.

Ectopic otoconial formation in the lagena of the pigeon inner ear.
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DOI:
10.1242/bio.034462
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发表时间:
2018-08-02
期刊:
影响因子:
2.4
通讯作者:
Keays DA
Keays DA
中科院分区:
生物学4区
文献类型:
--
作者:
Malkemper EP;Mason MJ;Kagerbauer D;Nimpf S;Keays DA

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脊椎动物的内耳含有前庭受体和致密的碳酸钙晶体,即耳蜗。耳蜗的产生和维持是一个微妙的过程,其扰动可导致人类严重的前庭功能障碍。这些过程的细节尚不清楚。在这里,我们报告了在成年鸽子的lagena中发现的一种新的耳锥肿块,这种肿块存在于超过70%的鸟类中。基于组织学、层析成像和元素分析,我们得出结论,该结构可能代表一个异位形成的耳锥组合。鉴于其频繁的自然发生,我们认为鸽子lagena是一个有价值的模型系统,用于研究耳锥体形成的失调。摘要:我们在鸽子lagena中发现了一个新的耳蜗群。该结构不受神经支配,也与毛细胞无关。我们的发现为异位耳锥形成提供了新的见解。
The vertebrate inner ear contains vestibular receptors with dense crystals of calcium carbonate, the otoconia. The production and maintenance of otoconia is a delicate process, the perturbation of which can lead to severe vestibular dysfunction in humans. The details of these processes are not well understood. Here, we report the discovery of a new otoconial mass in the lagena of adult pigeons that was present in more than 70% of birds. Based on histological, tomographic and elemental analyses, we conclude that the structure likely represents an ectopically-formed otoconial assembly. Given its frequent natural occurrence, we suggest that the pigeon lagena is a valuable model system for investigating misregulated otoconial formation. . Summary: We identified a new assembly of otoconia in the pigeon lagena. The structure is not innervated or associated with hair cells. Our finding provides new insights into ectopic otoconial formation.
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