Mechanisms of otoconia and otolith development.
Mechanisms of otoconia and otolith development.
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DOI：
10.1002/dvdy.24195
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Kramer KL
中科院分区：
文献类型：
--
作者：
Lundberg YW;Xu Y;Thiessen KD;Kramer KL
耳石是一种生物晶体，它将机械力耦合到椭圆囊和球囊中的感觉毛细胞，这是我们为了保持身体平衡而感知线性加速度和重力的必要过程。在鱼类中，被称为耳石的结构相似的生物晶体调节平衡和听觉。耳石异常是常见的，可导致眩晕和人类的不平衡。然而，这些疾病的分子病因尚不清楚，因为研究人员近年来才开始鉴定耳石形成的重要基因。迄今为止，已经对选定的小鼠耳石蛋白进行了深入研究，并且已经确定了大约75个斑马鱼基因对耳石发育很重要。本文就耳石发育与耳石形成的关系作一综述。它将提供一个更新的简要回顾耳锥蛋白沿着与概述的细胞和细胞过程参与。虽然需要继续努力，以彻底了解耳石和耳石发育的分子机制，很明显，这一过程涉及一系列的时间和空间的具体事件，是紧密协调的许多蛋白质。这些知识将成为揭示人类耳锥相关疾病的分子原因的基础。
Otoconia are bio-crystals which couple mechanic forces to the sensory hair cells in the utricle and saccule, a process essential for us to sense linear acceleration and gravity for the purpose of maintaining bodily balance. In fish, structurally similar bio-crystals called otoliths mediate both balance and hearing. Otoconia abnormalities are common and can cause vertigo and imbalance in humans. However, the molecular etiology of these illnesses is unknown, as investigators have only begun to identify genes important for otoconia formation in recent years. To date, in-depth studies of selected mouse otoconial proteins have been performed, and about 75 zebrafish genes have been identified to be important for otolith development. This review will summarize recent findings as well as compare otoconia and otolith development. It will provide an updated brief review of otoconial proteins along with an overview of the cells and cellular processes involved. While continued efforts are needed to thoroughly understand the molecular mechanisms underlying otoconia and otolith development, it is clear that the process involves a series of temporally and spatially specific events that are tightly coordinated by numerous proteins. Such knowledge will serve as the foundation to uncover the molecular causes of human otoconia-related disorders.
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影响因子：
2.5
作者：
Clendenon, Sherry G.;Shah, Bijal;Miller, Caroline A.;Schmeisser, Glen;Walter, Amanda;Gattone, Vincent H., II;Barald, Kate F.;Liu, Qin;Marrs, James A.
通讯作者：
Marrs, James A.
DOI：
10.1073/pnas.85.9.2919
发表时间：
1988-05-01
影响因子：
11.1
作者：
BOLANDER, ME;YOUNG, MF;TERMINE, JD
通讯作者：
TERMINE, JD
影响因子：
5.2
作者：
Alloisio, N;Morlé, L;Lina-Granade, G
通讯作者：
Lina-Granade, G
影响因子：
1.4
作者：
ANNIKO, M;YLIKOSKI, J;WROBLEWSKI, R
通讯作者：
WROBLEWSKI, R
影响因子：
9.8
作者：
Austin-Tse, Christina;Halbritter, Jan;Hildebrandt, Friedhelm
通讯作者：
Hildebrandt, Friedhelm