Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation.
Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation.
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DOI：
10.1007/s13311-021-01032-7
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Videnovic A
中科院分区：
文献类型：
--
作者：
St Louis EK;Videnovic A
我们发现自己处在目前的十字路口，拥有一个广为人知的工具包，也许太过陈旧，但对睡眠神经疗法领域充满了渴望和梦想。这卷是按主题组织成六个主题领域，平行于当代临床睡眠神经学实践的主要子专业领域，以及新的方向和机会。本问题首先概述了中枢性睡眠障碍，包括发作性睡病、特发性睡眠障碍和其他睡眠障碍，以及各种兴奋剂和促进觉醒的药物疗法的相关使用。接下来，对行为疗法的范围，光和光限制和褪黑素疗法的应用，以及用于失眠和昼夜睡眠-觉醒节律紊乱的催眠药物疗法进行了综述，然后概述了睡眠相关呼吸障碍的治疗选择，包括正压和阻塞性睡眠呼吸暂停的舌下神经刺激的新方法。然后讨论了睡眠障碍和与睡眠相关的运动障碍，包括觉醒的NREM障碍、REM睡眠障碍(噩梦和孤立性睡眠瘫痪和特发性/孤立的REM睡眠行为障碍)和不宁腿综合征，并对睡眠神经疗法在睡眠和神经疾病中的应用进行了综述，包括神经发育、癫痫、自身免疫性脑病和神经退行性疾病。最后，大麻素疗法和机器学习/人工智能方法为睡眠神经学提供了新的方向和机会，总结了这一当代睡眠神经学的全面调查。我们希望你会发现这本书是一个有用的和鼓舞人心的支持工具，用于最重要的工作，你在诊所里照顾我们所有的睡眠神经病患者。网上版载有补充材料，可在10.1007/s13311-021-01032-7查阅。
We find ourselves at our present crossroads with a well-traveled toolkit, perhaps too well worn but with aspirational hopes and dreams for the field of sleep neurotherapeutics. This volume is organized thematically into six topical domains that parallel the major subspecialty areas of contemporary clinical sleep neurology practice, as well as novel directions and opportunities. The issue begins with an overview of the central disorders of hypersomnolence, including narcolepsy, idiopathic hypersomnia and other hypersomnia disorders, and the related use of the entire broad range of stimulant and wake-promoting pharmacotherapies. Next, the range of behavioral therapies, application of light and light restriction and melatonin therapies, and hypnotic pharmacotherapies useful in insomnia and circadian sleep–wake rhythm disorders are reviewed, followed by an overview of treatment options for sleep-related breathing disorders including positive airway pressure and the novel approach of hypoglossal neurostimulation for obstructive sleep apnea. The parasomnias and sleep-related movement disorders, including NREM disorders of arousal, REM parasomnias (nightmares and isolated sleep paralysis and idiopathic/isolated REM sleep behavior disorder, and restless legs syndrome are then discussed, and the applications of sleep neurotherapeutics in sleep and neurological disease are reviewed, including neurodevelopmental, epileptic, autoimmune encephalopathies, and neurodegenerative diseases. Last, the novel directions and opportunities in sleep neurology offered by cannabinoid therapies and machine learning/artificial intelligence methodology conclude this comprehensive survey of contemporary sleep neurology. We hope that you find this volume to be a useful and inspirational support tool for the work that matters most, your care of all our sleep neurology patients in the clinics. The online version contains supplementary material available at 10.1007/s13311-021-01032-7.
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