Twelve Children with Varicella Vaccine Meningitis: Neuropathogenesis of Reactivated Live Attenuated Varicella Vaccine Virus.
Twelve Children with Varicella Vaccine Meningitis: Neuropathogenesis of Reactivated Live Attenuated Varicella Vaccine Virus.
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DOI：
10.3390/v12101078
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发表时间：
2020-09-25
期刊：
影响因子：
--
通讯作者：
Grose C
中科院分区：
文献类型：
--
作者：
Heusel EH;Grose C
水痘疫苗是一种减毒活水痘-带状疱疹病毒。像它的亲本毒株VZV Poka一样，疫苗病毒Voka保留了一些嗜神经的特性。为了更好地了解沃卡的神经发病机制，我们重新评估了12例已发表的沃卡脑膜炎病例，这些病例发生在一次免疫和两次免疫的儿童中，所有这些儿童在中枢神经系统感染之前都有带状疱疹发作。12例脑膜炎病例中有8例发生在只接受过一次免疫的儿童身上。从接种水痘疫苗到带状疱疹合并脑膜炎发病之间的时间间隔没有规律。其中4例脑膜炎病例发生在接受过两次免疫的儿童身上。由于所有四名儿童在诊断为脑膜炎时都是14岁，1岁时第一次接种疫苗到脑膜炎发作之间有很强的模式，即13年。对发病机制的了解需要了解带状疱疹的位置；大多数皮瘤皮疹发生在手臂或大腿的初级免疫部位，而眼部带状疱疹则不常见。基于这一文献综述，目前关于二次免疫儿童中水痘疫苗脑膜炎的原因还没有达成共识。
Varicella vaccine is a live attenuated varicella-zoster virus (VZV). Like its parental strain called VZV pOka, the vaccine virus vOka retains some neurotropic properties. To better understand vOka neuropathogenesis, we reassessed 12 published cases of vOka meningitis that occurred in once-immunized and twice-immunized children, all of whom had bouts of herpes zoster preceding the central nervous system infection. Eight of the 12 meningitis cases occurred in children who had received only one immunization. There was no pattern to the time interval between varicella vaccination and the onset of herpes zoster with meningitis. Four of the meningitis cases occurred in children who had received two immunizations. Since all four children were 14 years old when meningitis was diagnosed, there was a strong pattern to the interval between the first vaccination at age 1 year and onset of meningitis, namely, 13 years. Knowledge of pathogenesis requires knowledge of the location of herpes zoster; the majority of dermatomal rashes occurred at sites of primary immunization on the arm or thigh, while herpes zoster ophthalmicus was uncommon. Based on this literature review, currently there is no consensus as to the cause of varicella vaccine meningitis in twice-immunized children.
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影响因子：
8
作者：
Harrington, Whitney E.;Mato, Sayonara;Englund, Janet A.
通讯作者：
Englund, Janet A.
影响因子：
12.7
作者：
ECHEVARRIA, JM;CASAS, I;MARTINEZMARTIN, P
通讯作者：
MARTINEZMARTIN, P
影响因子：
9.4
作者：
GERSHON, A;STEINBERG, S;TABER, L
通讯作者：
TABER, L
影响因子：
3.6
作者：
GERSHON, AA
通讯作者：
GERSHON, AA
影响因子：
9.9
作者：
Haanpää, M;Dastidar, P;Nurmikko, T
通讯作者：
Nurmikko, T