Protective Effects of Polysaccharides in Neurodegenerative Diseases.
Protective Effects of Polysaccharides in Neurodegenerative Diseases.
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多糖对神经退行性疾病的保护作用
DOI：
10.3389/fnagi.2022.917629
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
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作者：
神经退行性疾病（ndds）以神经元进行性变性和坏死为特征，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病等。没有现有的治疗方法可以纠正这些疾病的进展，目前的治疗方法仅仅提供症状缓解。多糖因其广泛的生物活性和应用前景而受到重视。以往的研究表明，多糖作为一种候选物质参与神经元保护和抗NDs。在这篇综述中，我们证明了多种多糖介导NDs，并具有自噬、细胞凋亡、神经炎症、氧化应激、线粒体功能障碍等共同机制。此外，本文还揭示了多糖在nd体外和体内模型中的潜在作用，并重点介绍了多糖在nd治疗中的作用及其机制研究的前景。最后，提出了该领域有待解决的问题和新的发展方向。
Neurodegenerative diseases (NDs) are characterized by progressive degeneration and necrosis of neurons, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease and others. There are no existing therapies that correct the progression of these diseases, and current therapies provide merely symptomatic relief. The use of polysaccharides has received significant attention due to extensive biological activities and application prospects. Previous studies suggest that the polysaccharides as a candidate participate in neuronal protection and protect against NDs. In this review, we demonstrate that various polysaccharides mediate NDs, and share several common mechanisms characterized by autophagy, apoptosis, neuroinflammation, oxidative stress, mitochondrial dysfunction in PD and AD. Furthermore, this review reveals potential role of polysaccharides in vitro and in vivo models of NDs, and highlights the contributions of polysaccharides and prospects of their mechanism studies for the treatment of NDs. Finally, we suggest some remaining questions for the field and areas for new development.
影响因子：
2.9
作者：
Lee SW;Park HJ;Im W;Kim M;Hong S
通讯作者：
Hong S
DOI：
10.1177/1073858410386236
发表时间：
2011-04
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Southwell AL;Patterson PH
通讯作者：
Patterson PH