Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity.
Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity.
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父母接触双酚 A 及其类似物会影响斑马鱼后代的免疫力
DOI：
10.1016/j.scitotenv.2017.08.057
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Dong X;Zhang Z;Meng S;Pan C;Yang M;Wu X;Yang L;Xu H
环境污染物对人和动物的跨代影响是复杂的。因此，我们利用斑马鱼来评价双酚A及其类似物(双酚S和双酚F)对后代先天免疫功能的影响。在成年时，对后代进行检查，使用/不使用持续的化学处理，直到受精后72小时。为了测量后代的免疫功能，在72hpf的条件下，幼虫在病毒模拟聚肌胞苷酸(Poly I：C)或细菌模拟Pam3Cys-Ser-Lys4(PAM3CSK4)的作用下暴露24小时。数据显示，后代的免疫力发生了改变。具体地说，在F1幼虫中，溶菌酶活性被显著诱导，呼吸爆发反应和氧化防御基因被抑制。幼虫体内Toll样受体及其下游分子和炎性细胞因子等天然免疫系统基因表达显著下调，而基质金属蛋白酶基因表达显著上调。此外，未成熟适应性免疫系统中的重组激活基因显著减少。因此，将亲代斑马鱼暴露于环境相关浓度的双酚会降低免疫防御能力，这表明在野外长期暴露于双酚的鱼类可能容易受到病原体的攻击。双酚A及其类似物在斑马鱼后代中的生物积累通过转移亲本水基双酚负担。亲代接触双酚A及其类似物会降低斑马鱼后代的存活率。双酚A及其类似物对斑马鱼后代免疫功能的影响。亲代接触双酚A及其类似物可能会导致斑马鱼后代的健康状况下降。
Transgenerational effects of environmental pollutants on humans and animals are complex. Thus, we used zebrafish to evaluate the effects of parental whole-life cycle exposure to bisphenol A and its analogs (bisphenol S and F) on offspring innate immunity. At adulthood, offspring were examined with/without continued chemicals treatment until 72 h post-fertilization (hpf). To measure offspring immune function, larvae at 72 hpf were expose for 24 h with/without the viral mimic polyinosinic-cytidylic acid (Poly I:C) or the bacterial mimic Pam3Cys-Ser-Lys4 (PAM3CSK4). Data show modified immunity in offspring. Specifically, lysozyme activity was significantly induced in F1 larvae and respiratory burst response and oxidative defense genes were inhibited. Genes of the innate immune system including Toll-like receptors and their downstream molecules and inflammatory cytokines were significantly down-regulated, whereas matrix metalloproteinases were up-regulated in larvae. In addition, recombination-activating genes in the immature adaptive immune system were significantly reduced. Thus, immune defense is diminished by exposing parental generations of zebrafish to environmentally relevant concentration of bisphenols and this suggests that fish chronically exposed to bisphenols in the wild may be vulnerable to pathogens. Bisphenol A and its analogs bioaccumulated in zebrafish offspring via the transfer of parental waterborne bisphenols burdens. Parental exposure to bisphenol A and its analogs decreased survive of zebrafish offspring. Parental exposure to bisphenol A and its analogs influenced zebrafish offspring immunity. Parental exposure to bisphenol A and its analogs could result in a decreased healthy status in zebrafish offspring.
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3.8
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