AUGUSTUS: ab initio prediction of alternative transcripts.
AUGUSTUS: ab initio prediction of alternative transcripts.
复制标题
DOI:
10.1093/nar/gkl200
复制
发表时间:
2006-07-01
影响因子:
14.9
通讯作者:
Morgenstern B
中科院分区:
文献类型:
--
作者:
Stanke M;Keller O;Gunduz I;Hayes A;Waack S;Morgenstern B
AUGUSTUS is a software tool for gene prediction in eukaryotes based on a Generalized Hidden Markov Model, a probabilistic model of a sequence and its gene structure. Like most existing gene finders, the first version of AUGUSTUS returned one transcript per predicted gene and ignored the phenomenon of alternative splicing. Herein, we present a WWW server for an extended version of AUGUSTUS that is able to predict multiple splice variants. To our knowledge, this is the first ab initio gene finder that can predict multiple transcripts. In addition, we offer a motif searching facility, where user-defined regular expressions can be searched against putative proteins encoded by the predicted genes. The AUGUSTUS web interface and the downloadable open-source stand-alone program are freely available from .
登录
查看更多内容
影响因子:
5.8
作者:
Stanke, Mario;Waack, Stephan
通讯作者:
Waack, Stephan
影响因子:
7
作者:
Alexandersson, M;Cawley, S;Pachter, L
通讯作者:
Pachter, L
影响因子:
5.6
作者:
GUIGO, R;KNUDSEN, S;SMITH, T
通讯作者:
SMITH, T
影响因子:
3
作者:
Brudno, M;Chapman, M;Morgenstern, B
通讯作者:
Morgenstern, B
影响因子:
14.9
作者:
Stanke M;Morgenstern B
通讯作者:
Morgenstern B