Does stress induce (para)sex? Implications for Candida albicans evolution.
Does stress induce (para)sex? Implications for Candida albicans evolution.
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DOI：
10.1016/j.tig.2012.01.004
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发表时间：
2012-05
影响因子：
11.4
通讯作者：
Hadany, Lilach
中科院分区：
文献类型：
--
作者：
Berman, Judith;Hadany, Lilach
理论预测，压力是解释性在官能性生物（包括微生物）中进化作用的关键因素。能够有性和无性繁殖的生物体在受到压力时会更频繁地交配，这种压力诱导的交配预计会促进适应。在这里，我们提出，压力有一个类似的影响，在白色念珠菌，其中涉及二倍体和四倍体细胞之间的世代交替的准性周期。准性周期可以产生高水平的多样性，包括非整倍体，但它显然在自然界中很少发生。我们回顾的证据表明，压力有利于四个主要步骤的准性周期，并建议parasex englands更频繁地在压力条件下。这可以解释parasex的进化意义和它的明显罕见性。
Theory predicts that stress is a key factor in explaining the evolutionary role of sex in facultatively sexual organisms, including microorganisms. Organisms capable of reproducing both sexually and asexually are expected to mate more frequently when stressed, and such stress-induced mating is predicted to facilitate adaptation. Here, we propose that stress has an analogous effect on the parasexual cycle in Candida albicans, which involves alternation of generations between diploid and tetraploid cells. The parasexual cycle can generate high levels of diversity, including aneuploidy, yet it apparently occurs only rarely in nature. We review the evidence that stress facilitates four major steps in the parasexual cycle, and suggest that parasex ensues much more frequently under stress conditions. This may explain both the evolutionary significance of parasex and its apparent rarity.
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压力改变白色念珠菌中杂合性丧失的速率和类型。
影响因子：
6.4
作者：
Forche A;Abbey D;Pisithkul T;Weinzierl MA;Ringstrom T;Bruck D;Petersen K;Berman J
通讯作者：
Berman J
影响因子：
2.1
作者：
Hadany, L;Beker, T
通讯作者：
Beker, T
影响因子：
3.3
作者：
Hadany, Lilach;Otto, Sarah P.
通讯作者：
Otto, Sarah P.
影响因子：
3.2
作者：
Cowen, LE;Sanglard, D;Kohn, LM
通讯作者：
Kohn, LM
影响因子：
3.6
作者：
Bennett, Richard J.;Johnson, Alexander D.
通讯作者：
Johnson, Alexander D.