Epigenetics as a Mechanism of Developmental Embodiment of Stress, Resilience, and Cardiometabolic Risk Across Generations of Latinx Immigrant Families.
Epigenetics as a Mechanism of Developmental Embodiment of Stress, Resilience, and Cardiometabolic Risk Across Generations of Latinx Immigrant Families.
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DOI：
10.3389/fpsyt.2021.696827
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发表时间：
2021
影响因子：
4.7
通讯作者：
Non AL
中科院分区：
文献类型：
--
作者：
Clausing ES;Non AL
心理社会压力可以体现在整个生命过程中改变生物学的方式，可能会产生持久的健康后果。移民特别容易承受沉重的压力，而这种压力在当前的社会政治气候下更加严重。本研究是一项调查移民相关的压力（IRS）如何可能影响心脏代谢风险和表观遗传标记的拉丁移民母亲和儿童在纳什维尔，田纳西州。我们比较了拉丁裔移民母亲及其子女（5-13岁）在2016年美国总统大选的两个时间点（2015年6月至2016年6月基线，n = 81; 2018年3月至9月随访，n = 39）报告的压力和弹性因素与心脏代谢风险标志物（BMI，腰围和血压）。我们还分析了这些因素与通过亚硫酸氢盐焦磷酸测序产生的应激相关候选基因（SLC 6A 4和FKBP 5）的唾液中的DNA甲基化的关系（完整病例n的范围从67-72基线和29-31随访）（n的范围从80基线到36随访）。我们发现了与心脏代谢风险的各种关联，例如较高的社会支持和较大的文化适应与母亲的较低BMI相关;歧视和学校压力与儿童的腰围较大相关。与FKBP 5相关的暴露很少，但与SLC 6A 4许多位点的甲基化相关的各种压力源，包括母亲和儿童的移民相关压力，以及儿童对父母驱逐出境的恐惧。此外，在母亲中，总的母亲压力，健康压力和主观社会地位与SLC 6A 4多个位点的甲基化相关。文化适应与母亲这两个基因的甲基化相关，尽管影响方向随着时间的推移而变化。我们还发现SLC 6A 4的DNA甲基化与肥胖和血压的测量有关，这表明甲基化可能是连接压力与心脏代谢风险的途径。需要更多的研究来确定这些表观遗传差异在促进跨代压力体现方面的作用。
Psychosocial stressors can become embodied to alter biology throughout the life course in ways that may have lasting health consequences. Immigrants are particularly vulnerable to high burdens of stress, which have heightened in the current sociopolitical climate. This study is an investigation of how immigration-related stress (IRS) may impact the cardiometabolic risk and epigenetic markers of Latinx immigrant mothers and children in Nashville, TN. We compared stress and resilience factors reported by Latina immigrant mothers and their children (aged 5–13) from two time points spanning the 2016 U.S. presidential election (June 2015–June 2016 baseline, n = 81; March–September 2018 follow-up, n = 39) with cardiometabolic risk markers (BMI, waist circumference, and blood pressure). We also analyzed these factors in relation to DNA methylation in saliva of stress-related candidate genes (SLC6A4 and FKBP5), generated via bisulfite pyrosequencing (complete case n's range from 67–72 baseline and 29–31 follow-up) (n's range from 80 baseline to 36 follow-up). We found various associations with cardiometabolic risk, such as higher social support and greater acculturation were associated with lower BMI in mothers; discrimination and school stress associated with greater waist circumferences in children. Very few exposures associated with FKBP5, but various stressors associated with methylation at many sites in SLC6A4, including immigrant-related stress in both mothers and children, and fear of parent deportation in children. Additionally, in the mothers, total maternal stress, health stress, and subjective social status associated with methylation at multiple sites of SLC6A4. Acculturation associated with methylation in mothers in both genes, though directions of effect varied over time. We also find DNA methylation at SLC6A4 associates with measures of adiposity and blood pressure, suggesting that methylation may be on the pathway linking stress with cardiometabolic risk. More research is needed to determine the role of these epigenetic differences in contributing to embodiment of stress across generations.
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影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
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作者：
Garza, Jeremiah R.;Glenn, Beth A.;Zimmerman, Frederick J.
通讯作者：
Zimmerman, Frederick J.
影响因子：
6.8
作者：
Drabe, M.;Rullmann, M.;Hesse, S.
通讯作者：
Hesse, S.
影响因子：
11.3
作者：
Farrell, Chloe;Doolin, Kelly;O'Keane, Veronica
通讯作者：
O'Keane, Veronica
影响因子：
12.8
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Carver, Charles S.;Scheier, Michael F.;Segerstrom, Suzanne C.
通讯作者：
Segerstrom, Suzanne C.