Understanding the Role of Non-Coding RNAs in Bladder Cancer: From Dark Matter to Valuable Therapeutic Targets.
Understanding the Role of Non-Coding RNAs in Bladder Cancer: From Dark Matter to Valuable Therapeutic Targets.
复制标题
DOI：
10.3390/ijms18071514
复制
发表时间：
2017-07-13
影响因子：
5.6
通讯作者：
Berindan-Neagoe I
中科院分区：
文献类型：
--
作者：
Pop-Bica C;Gulei D;Cojocneanu-Petric R;Braicu C;Petrut B;Berindan-Neagoe I
膀胱癌的死亡率和发病率的特点迫使这种恶性肿瘤成为生物分子研究的热点。因此，需要更好地了解膀胱癌发生和发展的特定分子机制。相似诊断患者的肿瘤异质性以及肿瘤内的异质性给靶向治疗带来了困难。此外，晚期诊断是一个持续存在的问题，显著降低了对治疗的反应，不可避免地降低了总生存率。近十年来，非编码rna在膀胱癌中的作用逐渐显现，揭示了microRNAs （miRNAs）既可以作为肿瘤抑制基因、癌基因，也可以作为早期诊断的生物标志物。对于其他类型的非编码rna，特别是本文中广泛讨论的长链非编码rna (lncRNAs)，它们在肿瘤发生中的确切作用暂时不像miRNAs那样明显，但仍然清楚地表明。因此，本文综述膀胱癌患者及其已证实的靶基因在膀胱癌细胞系中的非编码RNA表达谱及其对细胞恶性转化的增殖、侵袭性、凋亡、细胞周期阻滞等分子途径的影响。
The mortality and morbidity that characterize bladder cancer compel this malignancy into the category of hot topics in terms of biomolecular research. Therefore, a better knowledge of the specific molecular mechanisms that underlie the development and progression of bladder cancer is demanded. Tumor heterogeneity among patients with similar diagnosis, as well as intratumor heterogeneity, generates difficulties in terms of targeted therapy. Furthermore, late diagnosis represents an ongoing issue, significantly reducing the response to therapy and, inevitably, the overall survival. The role of non-coding RNAs in bladder cancer emerged in the last decade, revealing that microRNAs (miRNAs) may act as tumor suppressor genes, respectively oncogenes, but also as biomarkers for early diagnosis. Regarding other types of non-coding RNAs, especially long non-coding RNAs (lncRNAs) which are extensively reviewed in this article, their exact roles in tumorigenesis are—for the time being—not as evident as in the case of miRNAs, but, still, clearly suggested. Therefore, this review covers the non-coding RNA expression profile of bladder cancer patients and their validated target genes in bladder cancer cell lines, with repercussions on processes such as proliferation, invasiveness, apoptosis, cell cycle arrest, and other molecular pathways which are specific for the malignant transformation of cells.
登录
查看更多内容
影响因子：
5.8
作者：
Chen XN;Wang KF;Xu ZQ;Li SJ;Liu Q;Fu DH;Wang X;Wu B
通讯作者：
Wu B
DOI：
10.3322/caac.21244
发表时间：
2014-09
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Berindan-Neagoe I;Monroig Pdel C;Pasculli B;Calin GA
通讯作者：
Calin GA
影响因子：
2.8
作者：
Canturk, Kemal Murat;Ozdemir, Muhsin;Artan, Sevilhan
通讯作者：
Artan, Sevilhan
影响因子：
8.8
作者：
通讯作者：
--
miR-193a-3p通过靶向LOXL4基因和氧化应激途径调节膀胱癌的多药耐药性。
影响因子：
37.3
作者：
Deng H;Lv L;Li Y;Zhang C;Meng F;Pu Y;Xiao J;Qian L;Zhao W;Liu Q;Zhang D;Wang Y;Zhang H;He Y;Zhu J
通讯作者：
Zhu J