Galectin-3 in patients with atrial fibrillation undergoing radiofrequency catheter ablation.
Galectin-3 in patients with atrial fibrillation undergoing radiofrequency catheter ablation.
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DOI：
10.1371/journal.pone.0123574
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Bollmann A
中科院分区：
文献类型：
--
作者：
Kornej J;Schmidl J;Ueberham L;John S;Daneschnejad S;Dinov B;Hindricks G;Adams V;Husser D;Bollmann A
半乳糖凝集素-3（Galectin-3，Gal-3）是心力衰竭中的一种新兴生物标志物，其参与纤维化和炎症。然而，其作为房颤（AF）预后标志物的潜在价值尚不清楚。本研究的目的是评估房颤导管消融对Gal-3的影响，并评价其对预测导管消融后心律结局的预后影响。在基线和6个月后使用特异性ELISA测量Gal-3。房颤复发定义为消融术后6个月内持续时间超过30秒的任何房性心律失常。在接受导管消融术的105名AF患者（65%男性，年龄62 ± 9岁，52%阵发性AF）中，在基线和6个月后测量了Gal-3，并与无AF对照队列（n = 14，50%男性，年龄58 ± 11岁）进行比较。AF患者中的Gal-3高于无AF对照组（7.8 ± 2.9 vs. 5.8 ± 1.8，ng/mL，p = 0.013）。然而，在多变量分析中，BMI（p = 0.007）而非AF（p = 0.068）与Gal-3相关。在AF队列中，在单变量分析中，较高的Gal-3水平与女性性别（p = 0.028）、较高的BMI（p = 0.005）以及CHADS 2（p = 0.008）和CHA2DS 2-VASC（p = 0.016）评分相关，然而，在多变量分析中，仅BMI仍与基线Gal-3显著相关（p = 0.016）。Gal-3在AF导管消融后6个月相似，与窦性心律维持无关。虽然AF患者的半乳糖凝集素-3水平较高，但这是由心脏代谢合并症而不是心律驱动的。Gal-3对预测导管消融术的心律结果没有帮助。
Galectin-3 (Gal-3) is an emerging biomarker in heart failure that is involved in fibrosis and inflammation. However, its potential value as a prognostic marker in atrial fibrillation (AF) is unknown. The aim of this study was to assess the impact of AF catheter ablation on Gal-3 and evaluate its prognostic impact for predicting rhythm outcome after catheter ablation. Gal-3 was measured at baseline and after 6 months using specific ELISA. AF recurrences were defined as any atrial arrhythmia lasting longer than 30 sec within 6 months after ablation. In 105 AF patients (65% males, age 62±9 years, 52% paroxysmal AF) undergoing catheter ablation, Gal-3 was measured at baseline and after 6 months and compared with an AF-free control cohort (n=14, 50 % males, age 58±11 years). Gal-3 was higher in AF patients compared with AF-free controls (7.8±2.9 vs. 5.8±1.8, ng/mL, p=0.013). However, on multivariable analysis, BMI (p=0.007) but not AF (p=0.068) was associated with Gal-3. In the AF cohort, on univariable analysis higher Gal-3 levels were associated with female gender (p=0.028), higher BMI (p=0.005) and both CHADS2 (p=0.008) and CHA2DS2-VASC (p=0.016) scores, however, on multivariable analysis only BMI remained significantly associated with baseline Gal-3 (p=0.016). Gal-3 was similar 6 months after AF catheter ablation and was not associated with sinus rhythm maintenance. Although galectin-3 levels are higher in AF patients, this is driven by cardiometabolic co-morbidities and not heart rhythm. Gal-3 is not useful for predicting rhythm outcome of catheter ablation.
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DOI：
10.1111/j.1540-8167.2011.02059.x
发表时间：
2011-09-01
影响因子：
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