The effects of IL-6 on CD4 T cell responses.

The effects of IL-6 on CD4 T cell responses.
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DOI:
10.1016/j.clim.2008.08.018
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发表时间:
2009-01
期刊:
Clinical immunology (Orlando, Fla.)
影响因子:
--
通讯作者:
Rincon M
Rincon M
中科院分区:
其他
文献类型:
--
作者:
Dienz O;Rincon M

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长期以来,人们已经知道细胞因子通过决定CD 4 T细胞分化而深刻地影响适应性免疫应答。尽管IL-6最初被表征为B细胞生长因子和抗体产生的诱导剂,但我们实验室和其他实验室的研究在过去几年中揭示了IL-6在CD 4 T细胞分化中也起重要作用。这篇综述强调了IL-6影响CD 4效应器功能的各种方式,以及这可能如何导致不同类型的疾病。
Cytokines have long been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our lab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation. This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases.
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