Regulatory T-cell-associated cytokines in systemic lupus erythematosus.
Regulatory T-cell-associated cytokines in systemic lupus erythematosus.
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DOI：
10.1155/2011/463412
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发表时间：
2011
影响因子：
--
通讯作者：
Yamamoto K
中科院分区：
文献类型：
--
作者：
Okamoto A;Fujio K;Okamura T;Yamamoto K
系统性红斑狼疮（SLE）是一种以自身抗体产生、补体活化和免疫复合物沉积为特征的自身免疫性疾病，可导致组织和器官损伤。了解体内平衡控制炎症的机制，包括先天免疫反应和过继免疫反应，将有助于开发SLE的新疗法。调节性T细胞（Treg）在诱导外周对自身和外源抗原的耐受中起着关键作用。自然产生的CD4+CD25+ Treg特征性地表达转录因子叉头盒蛋白P3 (Foxp3)，由于其缺乏会破坏自身耐受性并导致自身免疫性疾病，因此已被深入研究。此外，调节细胞因子如白细胞介素-10 （IL-10）也在控制炎症过程中发挥核心作用。本文重点研究treg及其相关细胞因子可能调控SLE的发病机制，具有临床应用价值。
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition, resulting in tissue and organ damage. An understanding of the mechanisms responsible for homeostatic control of inflammation, which involve both innate and adoptive immune responses, will enable the development of novel therapies for SLE. Regulatory T cells (Treg) play critical roles in the induction of peripheral tolerance to self- and foreign antigens. Naturally occurring CD4+CD25+ Treg, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been intensively studied because their deficiency abrogates self-tolerance and causes autoimmune disease. Moreover, regulatory cytokines such as interleukin-10 (IL-10) also play a central role in controlling inflammatory processes. This paper focuses on Tregs and Treg-associated cytokines which might regulate the pathogenesis of SLE and, hence, have clinical applications.
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