Effectiveness of BNT162b2 Vaccination During Pregnancy in Preventing Hospitalization for Severe Acute Respiratory Syndrome Coronavirus 2 in Infants.
Effectiveness of BNT162b2 Vaccination During Pregnancy in Preventing Hospitalization for Severe Acute Respiratory Syndrome Coronavirus 2 in Infants.
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DOI：
10.1016/j.jpeds.2022.09.059
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发表时间：
2023-03
影响因子：
5.1
通讯作者：
Youngster, Ilan
中科院分区：
文献类型：
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作者：
Danino, Dana;Ashkenazi-Hoffnung, Liat;Diaz, Alejandro;Erps, Amir Dov;Eliakim-Raz, Noa;Avni, Yonat Shemer;Greenberg, David;Givon-Lavi, Noga;Youngster, Ilan
评估怀孕期间 BNT162b2 疫苗预防婴儿严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 住院的临床效果。一项回顾性、多中心、1:3 病例对照（测试阴性）研究。将 2021 年 1 月 3 日至 2021 年 3 月 11 日期间 SARS-CoV-2 聚合酶链反应测试呈阳性、有症状的 6 个月以下住院婴儿按年龄和时间与阴性对照进行匹配，这些婴儿的住院症状与 SARS-CoV-2 感染相符。母亲被定义为已完全接种疫苗，接受 2 剂 BNT162b2，其中第二剂在分娩前 2 周至 6 个月接种；或部分疫苗接种，如果他们只接种了 1 剂或 2 剂，其中第二剂是在分娩前 6 个月以上或不到 2 周内接种的。严重 SARS-CoV-2 被定义为需要辅助通气。我们将 116 名 SARS-CoV-2 阳性婴儿与 348 名症状与 SARS-CoV-2 感染相符的阴性对照进行匹配。完全接种疫苗的母亲的有效性为 61.6%（95% CI，31.9-78.4），部分接种疫苗的母亲的有效性不显着。 0-2 个月婴儿的有效性高于 3-6 个月婴儿。当排除怀孕期间感染 SARS-CoV-2 的母亲时，有效性（57.1%；95% CI，22.8-76.4）相似。未接种疫苗与完全接种疫苗的母亲所生婴儿严重感染的 OR 为 5.8。在妊娠中期或晚期注射至少 2 剂 BNT162b2 疫苗，对于减少 6 个月以下婴儿因 SARS-CoV-2 感染住院的有效性为 61.6%。
To assess the clinical effectiveness of the BNT162b2 vaccine during pregnancy in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospitalizations of infants. A retrospective, multicenter, 1:3 case-control (test-negative) study. Symptomatic hospitalized infants less than 6 months of age, with a positive SARS-CoV-2 polymerase chain reaction test between January 3, 2021, and March 11, 2021, were matched by age and time to negative controls, hospitalized with symptoms compatible with SARS-CoV-2 infection. Mothers were defined as fully vaccinated who received 2 doses of BNT162b2 with the second given 2 weeks to 6 months before delivery; or partially vaccinated, if they received only 1 dose or 2 doses with the second given more than 6 months or less than 2 weeks before delivery. Severe SARS-CoV-2 was defined as a need for assisted ventilation. We matched 116 SARS-CoV-2 positive infants with 348 negative controls with symptoms compatible with SARS-CoV-2 infection. The effectiveness of fully vaccinated mothers was 61.6% (95% CI, 31.9-78.4) and the effectiveness of partially vaccinated mothers was not significant. Effectiveness was higher in infants 0-2 vs 3-6 months of age. The effectiveness (57.1%; 95% CI, 22.8-76.4) was similar when excluding mothers who were infected with SARS-CoV-2 during pregnancy. The OR of severe infection in infants born to unvaccinated vs fully vaccinated mothers was 5.8. At least 2 doses of BNT162b2 vaccine administered during the second or third trimester of pregnancy had an effectiveness of 61.6% in decreasing hospitalization for SARS-CoV-2 infection in infants less than 6 months of age.
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DOI：
10.15585/mmwr.mm7107e3
发表时间：
2022-02-18
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Halasa NB;Olson SM;Staat MA;Newhams MM;Price AM;Boom JA;Sahni LC;Cameron MA;Pannaraj PS;Bline KE;Bhumbra SS;Bradford TT;Chiotos K;Coates BM;Cullimore ML;Cvijanovich NZ;Flori HR;Gertz SJ;Heidemann SM;Hobbs CV;Hume JR;Irby K;Kamidani S;Kong M;Levy ER;Mack EH;Maddux AB;Michelson KN;Nofziger RA;Schuster JE;Schwartz SP;Smallcomb L;Tarquinio KM;Walker TC;Zinter MS;Gilboa SM;Polen KN;Campbell AP;Randolph AG;Patel MM;Overcoming COVID-19 Investigators;Overcoming COVID-19 Network
通讯作者：
Overcoming COVID-19 Network
影响因子：
3.8
作者：
Yarden Bilavski, Havazelet;Balanson, Sarit;Livni, Gilat
通讯作者：
Livni, Gilat
怀孕期间接种 COVID-19 疫苗：覆盖范围和安全性。
影响因子：
9.8
作者：
Blakeway H;Prasad S;Kalafat E;Heath PT;Ladhani SN;Le Doare K;Magee LA;O'Brien P;Rezvani A;von Dadelszen P;Khalil A
通讯作者：
Khalil A
影响因子：
120.7
作者：
Collier, Ai-ris Y.;McMahan, Katherine;Barouch, Dan H.
通讯作者：
Barouch, Dan H.
接种 BNT162b2 疫苗与孕妇 SARS-CoV-2 感染率之间的关系
影响因子：
120.7
作者：
Goldshtein, Inbal;Nevo, Daniel;Segal, Yaakov
通讯作者：
Segal, Yaakov