Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer.
Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer.
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肝细胞生长因子激活肿瘤基质成纤维细胞，促进胃癌的肿瘤发生。
DOI：
10.1016/j.canlet.2013.02.002
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发表时间：
2013-07
期刊：
影响因子：
9.7
通讯作者：
Wu XY, Chen XH, Zhou Q, Li P, Yu PQ, Li JF, Qu Y,
中科院分区：
文献类型：
--
作者：
Wu XY, Chen XH, Zhou Q, Li P, Yu PQ, Li JF, Qu Y,
Cancer-associated fibroblasts (CAFs), as the activated fibroblasts in tumor stroma, are important modifiers of tumor progression. However, the mechanisms underlying stromal fibroblast activation and their promotion of tumor growth remain largely unknown in gastric cancer. Here, we show that normal fibroblasts (NFs) from non-cancerous regions of gastric cancer exhibit the traits of CAFs when grown together with gastric cancer cells in vivo. Activation of NFs can be induced by co-culture with gastric cancer cells, while deprivation of hepatocyte growth factor (HGF) using a neutralizing antibody inhibits the activation of NFs. Moreover, we identify HGF as an important factor from CAFs that acts in a paracrine manner to promote tumorigenesis in vitro and in vivo. Taken together, these results suggest that HGF may play a pivotal role in the regulatory circuit between gastric cancer cells and stromal fibroblasts, and neutralization of HGF inhibits both activation and tumor-promoting properties of CAFs.
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在小鼠乳腺癌异种移植模型中，短暂的肿瘤-成纤维细胞相互作用通过 TGF-β 介导的机制增加了肿瘤细胞的恶性程度。
影响因子：
3.7
作者：
Stuelten CH;Busch JI;Tang B;Flanders KC;Oshima A;Sutton E;Karpova TS;Roberts AB;Wakefield LM;Niederhuber JE
通讯作者：
Niederhuber JE
DOI：
--
发表时间：
2013
期刊：
--
影响因子：
--
作者：
J. Ferlay;I. Soerjomataram;M. Ervik;R. Dikshit;S. Eser;C. Mathers
通讯作者：
J. Ferlay;I. Soerjomataram;M. Ervik;R. Dikshit;S. Eser;C. Mathers
影响因子：
2
作者：
C. W. Wu;C. Chi;T. Su;T. Liu;W. Lui;F. P'eng
通讯作者：
C. W. Wu;C. Chi;T. Su;T. Liu;W. Lui;F. P'eng
DOI：
10.1073/pnas.0401064101
发表时间：
2004-04-06
影响因子：
11.1
作者：
Kuperwasser, C;Chavarria, T;Weinberg, RA
通讯作者：
Weinberg, RA
DOI：
10.1186/1756-9966-29-66
发表时间：
2010-06-08
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Zhi K;Shen X;Zhang H;Bi J
通讯作者：
Bi J