Polydatin prevents angiotensin II-induced cardiac hypertrophy and myocardial superoxide generation
Polydatin prevents angiotensin II-induced cardiac hypertrophy and myocardial superoxide generation
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虎杖甙可预防血管紧张素 II 诱导的心脏肥大和心肌超氧化物的产生
DOI：
10.1177/1535370214561958
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
张琪
中科院分区：
文献类型：
--
作者：
张琪
我们的研究和其他最近的研究表明，白藜芦醇苷，白藜芦醇苷，具有抗氧化和心脏保护作用。本研究旨在观察虎杖苷对血管紧张素II诱导的心肌肥厚的直接影响，探讨虎杖苷在心肌保护中的潜在作用。结果表明，虎杖苷可剂量依赖性地阻断Ang II诱导的心肌细胞肥大，其机制与降低细胞表面积、[3 H]亮氨酸掺入、降低心房钠尿因子和β-肌球蛋白重链mRNA表达有关。此外，虎杖苷防止由血管紧张素II输液诱导的大鼠心脏肥大，心脏重量与体重比，心肌细胞的横截面积和肥大标志物的基因表达进行评估。进一步的研究表明，虎杖苷衰减血管紧张素II诱导的活性氧水平和NADPH氧化酶活性的增加，在体内和体外。虎杖苷还阻断了Ang II刺激的培养心肌细胞和Ang II灌注大鼠心脏中Nox 4和Nox 2表达的增加。我们的研究结果表明，白藜芦醇苷有可能通过抑制NADPH氧化酶活性和超氧化物的产生，以防止血管紧张素II介导的心肌肥大。这些观察结果可能为理解虎杖苷的心脏保护作用提供新的线索。
Our studies and others recently demonstrate that polydatin, a resveratrol glucoside, has antioxidative and cardioprotective effects. This study aims to investigate the direct effects of polydatin on Ang II-induced cardiac hypertrophy to explore the potential role of polydatin in cardioprotection. Our results showed that in primary cultured cardiomyocytes, polydatin blocked Ang II-induced cardiac hypertrophy in a dose-dependent manner, which were associated with reduction in the cell surface area and [3H]leucine incorporation, as well as attenuation of the mRNA expressions of atrial natriuretic factor and β-myosin heavy chain. Furthermore, polydatin prevented rat cardiac hypertrophy induced by Ang II infusion, as assessed by heart weight-to-body weight ratio, cross-sectional area of cardiomyocyte, and gene expression of hypertrophic markers. Further investigation demonstrated that polydatin attenuated the Ang II-induced increase in the reactive oxygen species levels and NADPH oxidase activity in vivo and in vitro. Polydatin also blocked the Ang II-stimulated increases of Nox4 and Nox2 expression in cultured cardiomyocytes and the hearts of Ang II-infused rats. Our results indicate that polydatin has the potential to protect against Ang II-mediated cardiac hypertrophy through suppression of NADPH oxidase activity and superoxide production. These observations may shed new light on the understanding of the cardioprotective effect of polydatin.
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影响因子：
1.9
作者：
D. Goldberg;E. Ng;A. Karumanchiri;E. Diamandis;G. Soleas
通讯作者：
D. Goldberg;E. Ng;A. Karumanchiri;E. Diamandis;G. Soleas
影响因子：
15.9
作者：
Schultz, JEJ;Witt, SA;Doetschman, T
通讯作者：
Doetschman, T
DOI：
--
发表时间：
2008-04
期刊：
Sheng li xue bao : [Acta physiologica Sinica]
影响因子：
--
作者：
Li-ping Zhang;Chang-ying Yang;Ying-Ping Wang;Fang Cui;Yi Zhang
通讯作者：
Li-ping Zhang;Chang-ying Yang;Ying-Ping Wang;Fang Cui;Yi Zhang
DOI：
10.1161/hypertensionaha.111.172700
发表时间：
2011-06
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Kurdi M;Booz GW
通讯作者：
Booz GW
DOI：
--
发表时间：
2009-07
期刊：
Se pu = Chinese journal of chromatography
影响因子：
--
作者：
Jing Dong;Hong Wang;L. Wan;Y. Hashi;Shizhong Chen
通讯作者：
Jing Dong;Hong Wang;L. Wan;Y. Hashi;Shizhong Chen